Family Based Tests of Association for Complex Diseases

复杂疾病关联的家庭测试

基本信息

  • 批准号:
    6685130
  • 负责人:
  • 金额:
    $ 32.54万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1998
  • 资助国家:
    美国
  • 起止时间:
    1998-09-30 至 2006-11-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The broad, long-term objective of this grant is to enable the discovery of genes underlying complex traits by the continued development of methods for family-based association tests. This class of tests has grown in popularity because they are robust to population admixture, and can be more powerful tests of linkage than conventional linkage tests in the presence of association between the trait and the marker. Interest in association strategies is growing with increasing recognition of the limitations of linkage strategies in localizing genes for complex diseases. Moreover, with the near completion of the map of the human genome, it will be feasible to obtain multiple single nucleotide polymorphisms (SNPs) in candidate genes of interest or regions of linkage; using multiple SNPs in family-based tests will provide a powerful strategy for finding disease genes. Initiatives devoted to the identification and mapping of SNP's throughout the genome are currently underway. Specifically, we plan to: 1. Develop several complementary tests for association between haplotypes composed from multiple tightly-linked markers and disease phenotypes when phase may be ambiguous and parents may not be available. 2. Develop new methods based on ranks for quantitative traits and time-to-onset data. 3. Develop an exact-test version of FBAT that will provide more accurate p-values when the number of informative families is small and/or a small alpha-level is used. 4. Incorporate analytic power calculations into FBAT which will enable users to determine the most powerful designs, select appropriate sample sizes and choose the most powerful tests. 5. Continue the development, updating, and maintenance of FBAT, our fully documented, user friendly software which provides a general strategy for implementing Family-Based Tests of Association (FBAT).
描述(由申请人提供):

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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NAN MCKENZIE LAIRD其他文献

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{{ truncateString('NAN MCKENZIE LAIRD', 18)}}的其他基金

FAMILY BASED TESTS OF ASSOCIATION FOR COMPLEX DISEASES
复杂疾病协会基于家庭的测试
  • 批准号:
    2891153
  • 财政年份:
    1998
  • 资助金额:
    $ 32.54万
  • 项目类别:
Family Based Tests of Association for Complex Diseases
复杂疾病关联的家庭测试
  • 批准号:
    6577113
  • 财政年份:
    1998
  • 资助金额:
    $ 32.54万
  • 项目类别:
FAMILY BASED TESTS OF ASSOCIATION FOR COMPLEX DISEASES
复杂疾病协会基于家庭的测试
  • 批准号:
    2801598
  • 财政年份:
    1998
  • 资助金额:
    $ 32.54万
  • 项目类别:
Family Based Tests of Association for Complex Diseases
复杂疾病关联的家庭测试
  • 批准号:
    7764804
  • 财政年份:
    1998
  • 资助金额:
    $ 32.54万
  • 项目类别:
Family Based Tests of Association for Complex Diseases
复杂疾病关联的家庭测试
  • 批准号:
    6987843
  • 财政年份:
    1998
  • 资助金额:
    $ 32.54万
  • 项目类别:
FAMILY BASED TESTS OF ASSOCIATION FOR COMPLEX DISEASES
复杂疾病协会基于家庭的测试
  • 批准号:
    6186654
  • 财政年份:
    1998
  • 资助金额:
    $ 32.54万
  • 项目类别:
Family Based Tests of Association for Complex Diseases
复杂疾病关联的家庭测试
  • 批准号:
    7201914
  • 财政年份:
    1998
  • 资助金额:
    $ 32.54万
  • 项目类别:
Family Based Tests of Association for Complex Diseases
复杂疾病关联的家庭测试
  • 批准号:
    6826253
  • 财政年份:
    1998
  • 资助金额:
    $ 32.54万
  • 项目类别:
Family Based Tests of Association for Complex Diseases
复杂疾病关联的家庭测试
  • 批准号:
    7335568
  • 财政年份:
    1998
  • 资助金额:
    $ 32.54万
  • 项目类别:
Family Based Tests of Association for Complex Diseases
复杂疾病关联的家庭测试
  • 批准号:
    7535271
  • 财政年份:
    1998
  • 资助金额:
    $ 32.54万
  • 项目类别:
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