Collaborative Pediatric Bipolar Disorder Conference

描述（由申请人提供）：我们正在提议一个多年的会议 基金旨在为研究人员建立一个论坛， 儿童躁郁症的研究。该应用程序是在 对NIMH主任最近召开的圆桌会议的回应，博士。 史蒂夫·海曼与发展精神病理学合作， 预防研究分支和儿童与青少年治疗及 预防干预研究分支。尽管存在争议， 儿童双相情感障碍是非常罕见的， 报告和新的研究结果表明，这种疾病可能不会 这是罕见的，而是很难诊断。也很清楚 尽管对疾病分类学问题存在争议，但许多临床医生认识到， 相当多的儿童患有严重的精神病 与极端易怒、暴力和丧失能力有关， 很可能是躁郁症由于相当大的临床人群 目前存在相对较少的系统信息， 可用，努力提高研究的速度和效用， 迫切需要的。因此，一个旨在促进 首先需要研究者和临床医生之间的定期沟通， 建立合作研究和指导临床工作的步骤， 促进采取更有效和更精简的办法， 治疗这种令人困惑的疾病。拟议会议的主要目的是 赠款是为了克服合作的障碍， 研究儿童双相情感障碍的研究人员之间的会议。子目标 这些会议是：（1）定义两极频谱的边界 表型，并确定技术上符合双相情感障碍标准的儿童 实际上患有这种疾病或受另一种疾病的影响。 (2)标准化不同中心的数据收集方法， 促进诊断数据的汇集和疾病的验证;（3） 促进大型合作项目的联合提交， 研究广泛的科学问题，包括遗传学， 成像和治疗方案;以及（4）创建用于汇集的机制 样本，以便来自一个组的潜在发现可以交叉验证 其他组的汇总数据。尽管研究儿科的科学项目 双相情感障碍很可能在未来几年得到资助，这些努力 可能需要很多年才能展现出来这种科学空白和持续的 诊断和治疗的不确定性要求立即采取行动， 临床和科学领域相关方之间的联系和对话 社区虽然该领域面临着信息匮乏，但越来越多的 儿童和家庭被转介到诊所进行评估， 治疗因此，采取步骤，提高儿童的识别与 双相谱系障碍和初始治疗方法的发展 帮助他们具有高度的临床、科学和公共卫生重要性。 虽然拟议的会议并不打算解决所有悬而未决的问题 它将提供一个论坛，开始 配制溶液。

DESCRIPTION (provided by applicant): We are proposing a multi-year conference grant which seeks to establish a forum for researchers to pursue collaborative studies of pediatric bipolar disorder. This application was conceived in response to a recent roundtable discussion convened by the NIMH's Director, Dr. Steve Hyman, in collaboration with the Developmental Psychopathology and Prevention Research Branch and the Child and Adolescent Treatment and Preventive Intervention Research Branch. Despite controversy, the notion that pediatric bipolar disorder is exceedingly rare has been challenged by case reports and emerging research findings that suggest that this disorder may not be rare but, rather, that it is difficult to diagnose. It is also quite clear that, despite debate over nosological issues, many clinicians recognize that a sizable number of children suffer from a severe form of psychopathology associated with extreme irritability, violence, and incapacitation that is highly suggestive of bipolar disorder. Since a sizable clinical population currently exists for which relatively little systematic information is available, efforts that increase the pace and utility of research are desperately needed. Thus, an appropriate mechanism designed to facilitate regular communication among investigators and clinicians is needed as a first step to build collaborative research and guide clinical efforts that will foster a more efficient and streamlined approach to the understanding and treatment of this perplexing disorder. The main aim of the proposed conference grant is to overcome the hurdles to collaboration by establishing yearly conferences among investigators studying pediatric bipolar disorder. Subgoals of these conferences are: (1) to define the boundaries of the bipolar spectrum phenotype and determine if children who technically meet criteria for bipolar disorder actually have this disorder or are affected with another condition.; (2) to standardize data collection methods across different centers to facilitate pooling of diagnostic data and validation of the disorder; (3) to facilitate joint submissions of large collaborative projects that will enable the study of a broad spectrum of scientific questions including genetic, imaging and therapeutic protocols; and (4) to create a mechanism for pooling samples so that potential findings from one group may be cross-validated on pooled data from other groups. Although scientific projects studying pediatric bipolar disorder are likely to be funded in the coming years, these efforts will likely take many years to unfold. This scientific void and ongoing diagnostic and therapeutic uncertainties calls for immediate action to foster contact and dialogue among interested parties in the clinical and scientific community. While the field faces a dearth of information, more and more children and families are being referred to clinics for evaluation and treatment. Thus, steps that increase the identification of children with bipolar spectrum disorder and the development of initial therapeutic approaches to help them is of high clinical, scientific and public health importance. While the proposed conference does not intend to solve all outstanding problems associated with pediatric bipolar disorder, it will provide a forum to begin formulating a solution.