Micro-environment Glasses as a Treatment for CVS

计算机视觉综合症（CVS）是指与计算机使用相关的一系列眼部问题，大约四分之三的计算机用户患有这种疾病。保守估计表明，目前用于CVS治疗的检查和特殊眼镜的费用超过20亿美元。CVS最常见的症状包括：眼睛疲劳或眼睛疲劳，眼睛干燥，眼睛灼热，对光敏感和视力模糊。非眼部症状包括头痛，肩部，颈部或背部疼痛。尽管症状多种多样，但它们可能相关，并可细分为三种潜在的病理生理原因： 1)眼表机制 2)预防机制 3)眼外机制 关于这种疾病的诊断，知识基金存在重大缺口。在短期内，我们计划将重点放在眼表疾病类别作为CVS的原因，确定与此综合征相关的临床条件，并开发解决此原因的治疗方法。在第一阶段，我们建议： 通过观察有症状受试者的眼表异常发生率，并将其与年龄和性别匹配的无症状对照人群进行比较，在临床上定义CVS 开发专门的微环境眼镜来对抗CVS症状 研究微环境眼镜在症状人群和对照人群中的疗效 对CVS微环境玻璃作为商业产品的可行性进行严格评估 使用统计方法和主观问卷。

DESCRIPTION (provided by applicant) Computer Vision Syndrome (CVS) refers to a collection of eye problems associated with computer use, and about three-quarters of computer users have it. Conservative estimates indicate that over $2 billion is currently spent on examinations and special eyewear for CVS treatment. The most common symptoms of CVS include: eyestrain or eye fatigue, dry eyes, burning eyes, sensitivity to light, and blurred vision. Non-ocular symptoms include headaches, pain in the shoulders, neck, or back. As diverse as the symptoms are, they may be related and can be subdivided into to three potential pathophysiological causes: 1) Ocular Surface Mechanisms 2) Accommodative Mechanisms 3) Extra-Ocular Mechanisms There is a significant gap in the fund of knowledge regarding the diagnosis of this disease. In the near-term, we plan to focus on the ocular surface category of disorders as a cause of CVS, identify clinical conditions associated with this syndrome and develop a treatment that addresses this cause. In phase 1, we propose to: Clinically define CVS by observing the incidence of ocular surface abnormalities in symptomatic subjects and compare them with an age and sex matched non-symptomatic control population Develop specialized micro-environment glasses to combat CVS symptoms Study the efficacy of micro-environment glasses in symptomatic and control populations Critically evaluate viability of CVS micro-environment glasses as a commercial product using both statistical methods and subjective questionnaires.