Lung tumor detection using biomagnetic imaging

使用生物磁成像检测肺部肿瘤

• 批准号: 6783687
• 负责人: Laurel Owen Sillerud
• 金额: $ 23.54万
• 依托单位: FELDMATECH, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-11 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6783687
• 关键词: antibody; bioimaging /biomedical imaging; biomagnetism measurement; biosensor device; diagnosis design /evaluation; early diagnosis; fiber optics; lung imaging /visualization /scanning; lung neoplasms; method development; nanotechnology; neoplasm /cancer radiodiagnosis; particle; tumor antigens

DESCRIPTION (provided by applicant): Lung career in the United States is one of the leading causes of death, with 177,000 new cases yearly, resulting in a death rate of 158,000 people per year (1,2). There are more deaths from lung cancer than from prostate, breast and colorectal cancers combined. Unfortunately, the vast majority of lung tumors re clinically silent until the disease is terminal. Since early diagnosis can increase survival of lung cancer patients by up to 85%, new diagnostic methods are urgently needed. We propose to develop novel, high-sensitivity imaging of magnetic nanoparticles to provide specific diagnostic images of early lung tumors and potential distant metastases. Exciting recent developments in giant magnetostrictive (GMS) or magnetic shape memory (MSM) materials have led to the possibility of developing small, low-cost, room-temperature, portable, high-sensitive, fiber-optic sensors capable of robustly detecting magnetic nanopadicles, without direct contact with the skin. Magnetic nanoparticles will be conjugated with antibodies, which will target them to lung tumors. However, the technical challenges associated with developing GMS or MSM materials into deployable biomagnetic sensor arrays remain to be addressed. This Phase I proposal seeks to develop a working sensor array capable of detecting the magnetic signals produced by these nanoparticles in the lung. Therefore, overall the aim of the present proposal is: The construction, calibration and demonstration on of a prototype fiber-optic biomagnetic sensor array, based on giant magnetostrictive or magnetic shape memory materials, with the requisite sensitivity to image the magnetic signals generated by antibody-labeled magnetic nanoparticles in lung tumors.

描述（由申请人提供）： 在美国，肺部疾病是死亡的主要原因之一，每年有177，000例新发病例，导致每年158，000人的死亡率（1，2）。肺癌死亡人数超过前列腺癌、乳腺癌和结肠直肠癌死亡人数的总和。不幸的是，绝大多数肺肿瘤在临床上是沉默的，直到疾病是终端。由于早期诊断可以将肺癌患者的生存率提高85%，因此迫切需要新的诊断方法。我们建议开发新的，高灵敏度的磁性纳米粒子成像，以提供早期肺肿瘤和潜在的远处转移的特异性诊断图像。超磁致伸缩（GMS）或磁性形状记忆（MSM）材料的令人兴奋的最新发展已经导致开发小型、低成本、室温、便携式、高灵敏度的光纤传感器的可能性，所述光纤传感器能够鲁棒地检测磁性纳米棒，而不与皮肤直接接触。磁性纳米粒子将与抗体结合，抗体将使它们靶向肺部肿瘤。然而，与将GMS或MSM材料开发成可部署的生物磁传感器阵列相关的技术挑战仍有待解决。该第一阶段提案旨在开发一种能够检测肺部中这些纳米颗粒产生的磁信号的工作传感器阵列。因此，本提案的总体目标是： 基于超磁致伸缩或磁性形状记忆材料的原型光纤生物磁传感器阵列的构建、校准和演示，具有必要的灵敏度以成像由肺肿瘤中的抗体标记的磁性纳米颗粒产生的磁信号。