Lung tumor detection using biomagnetic imaging

描述(由申请人提供)： 在美国，肺病是导致死亡的主要原因之一，每年新增17.7万例，导致每年15.8万人死亡(1，2)。死于肺癌的人数比前列腺癌、乳腺癌和结直肠癌的总和还要多。不幸的是，绝大多数肺部肿瘤在临床上都是沉默的，直到疾病晚期。由于早期诊断可以提高肺癌患者的生存率高达85%，因此迫切需要新的诊断方法。我们建议开发新的、高灵敏度的磁性纳米粒子成像，以提供早期肺肿瘤和潜在远处转移的特异性诊断图像。超磁致伸缩(GMS)或磁形状记忆(MSM)材料的令人振奋的最新发展使开发小型、低成本、室温、便携式、高灵敏度的光纤传感器成为可能，能够在不与皮肤直接接触的情况下牢固地检测磁性纳米棒。磁性纳米粒子将与抗体偶联，抗体将靶向肺部肿瘤。然而，与将GMS或MSM材料开发成可展开的生物磁传感器阵列相关的技术挑战仍然有待解决。这项第一阶段的提案旨在开发一种工作传感器阵列，能够检测这些纳米颗粒在肺部产生的磁信号。因此，本提案的总体目标是： 基于超磁致伸缩或磁形状记忆材料的光纤生物磁传感器阵列原型的构建、校准和演示，具有对抗体标记的磁性纳米颗粒在肺部肿瘤中产生的磁信号进行成像所需的灵敏度。

DESCRIPTION (provided by applicant): Lung career in the United States is one of the leading causes of death, with 177,000 new cases yearly, resulting in a death rate of 158,000 people per year (1,2). There are more deaths from lung cancer than from prostate, breast and colorectal cancers combined. Unfortunately, the vast majority of lung tumors re clinically silent until the disease is terminal. Since early diagnosis can increase survival of lung cancer patients by up to 85%, new diagnostic methods are urgently needed. We propose to develop novel, high-sensitivity imaging of magnetic nanoparticles to provide specific diagnostic images of early lung tumors and potential distant metastases. Exciting recent developments in giant magnetostrictive (GMS) or magnetic shape memory (MSM) materials have led to the possibility of developing small, low-cost, room-temperature, portable, high-sensitive, fiber-optic sensors capable of robustly detecting magnetic nanopadicles, without direct contact with the skin. Magnetic nanoparticles will be conjugated with antibodies, which will target them to lung tumors. However, the technical challenges associated with developing GMS or MSM materials into deployable biomagnetic sensor arrays remain to be addressed. This Phase I proposal seeks to develop a working sensor array capable of detecting the magnetic signals produced by these nanoparticles in the lung. Therefore, overall the aim of the present proposal is: The construction, calibration and demonstration on of a prototype fiber-optic biomagnetic sensor array, based on giant magnetostrictive or magnetic shape memory materials, with the requisite sensitivity to image the magnetic signals generated by antibody-labeled magnetic nanoparticles in lung tumors.