Small Animal Handling Devices for Multiplatform Imaging

用于多平台成像的小动物处理设备

• 批准号: 6789574
• 负责人: STANLEY THOMAS FRICKE
• 金额: $ 14.7万
• 依托单位: ASI INSTRUMENTS, INC
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2005-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6789574
• 关键词: animal colony; bioimaging /biomedical imaging; biomedical equipment; biomedical equipment development; image processing; imaging /visualization /scanning; monitoring device; neurosciences; radiology; restraint; stereotaxic techniques; surgery

DESCRIPTION (provided by applicant): Small animal imaging initiatives are growing rapidly due to the enormous potential for improved understanding and treatment of human disease through animal imaging. At present, every radiologic modality available for use in humans has been adapted for small animal use. Other modalities have been devised solely for the purpose of in vivo imaging of research animals. As investigators increasingly make use of small animal imaging, the need for improved and standardized animal handling technology is critical. Our research goal is to create and distribute animal handling systems that are robust, safe, easy to use, and able to provide high-quality radiological images across multiple imaging platforms including MRI, CAT, PET and SPECT. The Specific Aims are to (1) Test and improve a stereotaxic rodent holder for rat and mouse head imaging, (2) Test and enhance animal monitoring and physiological support for the modular animal handling system, and (3) Evaluate the ability to use the rodent holder in multi-modality imaging applications. This proposed research is the result of a partnership between a small business specializing in the manufacture of animal handling devices (ASI Instruments, Inc.) and a university based research team (Neurobiological Magnetic Resonance Imaging Laboratory, Department of Neuroscience, Georgetown University). This industry/academic partnership will merge of the technology of stereotaxic instrumentation, typically used for the precise anatomical alignment needed in surgical procedures, and the technology of radiological imaging, in order to precisely align small animals to the orthogonal imaging planes of medical imaging equipment. Knowledge gained from this Phase I study will be used in Phase II for developing animal holders for other animals and for purposes other than imaging the brain of these animals (e.g. skeletal muscle, spinal cord, heart, lung, etc.).

描述（由申请人提供）：由于通过动物成像改善对人类疾病的理解和治疗的巨大潜力，小型动物成像计划的增长迅速。目前，每种可用于人类使用的放射学方式都适用于小动物的使用。仅出于研究动物的体内成像而设计了其他方式。随着研究人员越来越多地利用小型动物成像，对改进和标准化的动物处理技术的需求至关重要。我们的研究目标是创建和分发具有强大，安全，易于使用的动物处理系统，并能够在包括MRI，CAT，PET和SPECT在内的多个成像平台上提供高质量的放射学图像。具体目的是（1）测试和改善对大鼠和小鼠头像成像的立体定位啮齿动物​​固定器，（2）测试并增强对模块化动物处理系统的动物监测和生理支持，以及（3）评估在多模态成像应用中使用啮齿动物持有者的能力。这项拟议的研究是由专门从事动物处理设备（ASI Instruments，Inc。）的小型企业与大学研究团队（乔治敦大学神经科学系神经磁共振成像实验室）之间建立合作伙伴关系的结果。这种行业/学术伙伴关系将融合立体定位仪器的技术，通常用于手术过程中所需的精确解剖对齐，以及放射学成像技术，以便将小动物精确地与医学成像设备的正交成像平面相提并论。从本阶段研究中获得的知识将在第二阶段使用，用于开发其他动物的动物持有者，并出于对这些动物的大脑（例如骨骼肌，脊髓，心脏，心脏，肺等）进行成像以外的其他目的。