Thermoacoustic Imaging For Breast Cancer Detection

用于乳腺癌检测的热声成像

• 批准号: 6784364
• 负责人: JIAN LI
• 金额: $ 10万
• 依托单位: PLANNING SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6784364
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; breast neoplasm /cancer diagnosis; breast neoplasms; clinical biomedical equipment; clinical research; early diagnosis; image processing; imaging /visualization /scanning; microwave radiation; neoplasm /cancer radiodiagnosis; phantom model

DESCRIPTION (provided by applicant): This proposal describes a research program to develop an experimental prototype ultrawideband stepped frequency microwave-induced thermoacoustic imaging (TAI) system to image a breast phantom. Recent studies have shown that imaging the human breast for cancer detection with microwave-induced thermoacoustic waves is a viable technology. This new technology has many desirable properties of an ideal early breast cancer screener including being noninvasive, safe, comfortable, inexpensive, sensitive (to tumors), and specific (to cancers). Indeed, microwave-induced TAI combines the merits of both microwave stimulation, which provides excellent contrast between cancerous and normal breast tissue, and acoustic imaging, which has the advantage of very fine millimeter range spatial resolution. However, so far the experimental imaging results of real human breast are much poorer than those obtained under rather idealistic experimental setup. The goal of this study is to identify the key problems encountered by the microwaveinduced TAI under the realistic conditions of human breast imaging and propose innovative techniques to mitigate these problems, during Phase I of the fast-track application: 1. develop a prototype ultrawideband stepped-frequency microwave-induced TAI system to image a breast phantom, 2. demonstrate the benefits of multiple frequency stimulation for breast phantom anomaly detection, and 3. demonstrate the merits of using adaptive signal processing algorithms for thermoacoustic image formation and breast phantom anomaly detection. By the completion of this study, we will have developed and evaluated an experimental prototype ultrawideband stepped frequency microwave-induced TAI system to image a breast phantom. We will have obtained sufficient supporting evidence and experience for the Phase II efforts. We finally anticipate that the results of this and subsequent studies will provide new opportunities in a wide range of multidisciplinary studies ranging from electromagnetics and acoustics to adaptive beamforming for thermoacoustic image formation and pattern recognition for early cancer detection.

描述（由申请人提供）： 该提案描述了一个研究计划，以开发一个实验原型超宽带步进频率微波诱导热声成像（TAI）系统的图像乳房体模。最近的研究表明，利用微波诱导的热声波对人类乳腺进行成像以检测癌症是一种可行的技术。这项新技术具有理想的早期乳腺癌筛查的许多理想特性，包括无创，安全，舒适，廉价，敏感（对肿瘤）和特异性（对癌症）。事实上，微波诱导的TAI结合了微波刺激和声学成像两者的优点，微波刺激提供了癌组织和正常乳腺组织之间的良好对比，声学成像具有非常精细的毫米范围空间分辨率的优点。然而，到目前为止，真实的人体乳房的实验成像结果比在相当理想的实验装置下获得的成像结果差得多。本研究的目的是确定在人类乳腺成像的现实条件下微波诱导TAI遇到的关键问题，并提出创新技术来缓解这些问题，在快速通道应用的第一阶段：1。开发一个原型超宽带步进频率微波诱导TAI系统成像乳房体模，2。证明多频率刺激用于乳房体模异常检测的益处，以及3.证明了使用自适应信号处理算法用于热声图像形成和乳房体模异常检测的优点。通过这项研究的完成，我们将开发和评估一个实验原型超宽带步进频率微波诱导TAI系统成像乳房体模。我们将为第二阶段的工作获得足够的支持证据和经验。最后，我们预计，这项研究和后续研究的结果将提供新的机会，在广泛的多学科研究，从电磁学和声学自适应波束形成热声图像形成和模式识别早期癌症检测。