Integrated Technology Resource for Polymeric Biomaterials

描述(由申请人提供)：在了解细胞生物学、伤口愈合和靶向药物效应方面的不断进步正在以前所未有的方式为可降解、生物兼容聚合物的使用创造机会。聚合物生物材料资源(RESBIO)将通过a)合成和加工、b)微米和纳米尺度结构确定以及3)两种材料的表征及其与细胞的相互作用的综合技术，将先进的材料科学带给生物医学界的服务。利用这些技术之间的关系最终控制细胞反应是推进生物材料临床应用的有力途径；这是RESBIO的中心战略。一个独特的资源集群将由新泽西州生物材料中心创建和主办，该中心是新泽西州一流高等教育机构的一个蓬勃发展的学术联盟。该资源将专注于聚合物生物材料的合成，将生产扩大到千克级，利用材料科学、工程学和分子生物学技术进行加工，并表征大宗材料的性能。RESBIO将与NCRR资助的国家ESCA和生物医学问题表面分析中心(NESAC/BIO)密切互动，并对其进行补充。核心技术研发项目将侧重于聚合物设计的组合和计算方法、高通量和生物悬浮剂表征、整体生物材料微纳米结构的剖析以及原位细胞剖析。合作将涉及基础生化/生物材料研究和医疗设备的开发，如韧带置换和血管移植。RESBIO实验室将提供涵盖平行聚合物合成、聚合物加工、电子能量损失光谱和多光子共焦显微镜的综合服务。传播活动将以学术出版物、专业发展短期课程和讲习班、会议和海报演示以及一个综合网站为特色。一项广泛的培训计划将包括NIH资助的培训计划中的博士后住院医师和研究生课程。

DESCRIPTION (provided by applicant): Ongoing advances in understanding cell biology, wound healing and targeted drug effects are creating opportunities for the use of degradable, biocompatible polymers in unprecedented ways. The Resource for Polymeric Biomaterials, RESBIO, will bring advanced materials science to the service of the biomedical community through integrated technologies for a) synthesis and processing, b) micro- and nanoscale structure determination, and 3) characterization of both materials and their interactions with cells. Taking advantage of the relationships among these technologies for the ultimate control of cellular responses is a powerful approach to advancing clinical applications of biomaterials; this is the central strategy of RESBIO. A distinctive resource cluster will be created and hosted by the New Jersey Center for Biomaterials, a thriving academic consortium of New Jersey's premier institutions of higher education. This resource will focus on the synthesis of polymer biomaterials, scale-up of production to kilogram levels, processing, and characterization of bulk material properties using the techniques of materials science, engineering, and molecular biology. RESBIO will interact closely with and complement the NCRR-funded National ESCA and Surface Analysis Center for Biomedical Problems (NESAC/BIO). Core technological R&D projects will focus on combinatorial and computational approaches to polymer design, high-throughput and biorelevant characterization, profiling bulk biomaterial micro- and nanostructure, and in situ cell profiling. Collaborations will involve both basic biochemical/biomaterials research and the development of medical devices such as ligament replacements and vascular grafts. RESBIO laboratories will provide integrated services spanning parallel polymer synthesis, polymer processing, electron energy loss spectroscopy, and multiphoton confocal microscopy. Dissemination activities will feature scholarly publications, professional development short courses and workshops, conference and poster presentations, and a comprehensive website. A broad training program will include postdoctoral residencies in an NIH-funded training program and graduate courses.