Investigation into the biochemical and biological effects of air pollution on the function of human skin and the intervention of such effects

环境污染在全球范围内显著增加，污染物对人类健康（包括皮肤）的影响日益受到关注。氧化应激的产生被认为是颗粒物和臭氧发挥其有害作用的机制之一。该项目将调查空气污染对人体皮肤功能的生物化学和生物学影响以及对这种影响的干预。该研究的结果将与其他外部压力源（例如生活方式和太阳光）进行考虑。该项目将受益于纽卡斯尔大学和禾大欧洲有限公司经验丰富的监督团队。该项目涉及多学科，包括细胞、分子生物学和生理学技术、图像分析、细胞培养、遗传和化学分析、免疫染色和基因表达。

Ambient pollution is increasing significantly worldwide and the impact of pollutants on human health including skin is a growing concern. Generation of oxidative stress is implicated as one of the mechanisms by which particulate matter and ozone exert their deleterious effects. The project will investigate the biochemical and biological effects of air pollution on the function of human skin and the intervention of such effects. The outcomes of the study will be considered in relation to other external stressors such as lifestyle and Solar light. The project will benefit from an experienced supervisory team at Newcastle University and Croda Europe Limited. This project is multi-disciplinary including cellular, molecular biological and physiological techniques, image analysis, cell culture, genetic and chemical analysis, immunostaining and gene expression.