Investigation into the biochemical and biological effects of air pollution on the function of human skin and the intervention of such effects

空气污染对人体皮肤功能的生化、生物学影响及其干预研究

• 批准号: 2314361
• 金额: --
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2314361
• 关键词: Investigation; into; biochemical; biological; effects

Ambient pollution is increasing significantly worldwide and the impact of pollutants on human health including skin is a growing concern. Generation of oxidative stress is implicated as one of the mechanisms by which particulate matter and ozone exert their deleterious effects. The project will investigate the biochemical and biological effects of air pollution on the function of human skin and the intervention of such effects. The outcomes of the study will be considered in relation to other external stressors such as lifestyle and Solar light. The project will benefit from an experienced supervisory team at Newcastle University and Croda Europe Limited. This project is multi-disciplinary including cellular, molecular biological and physiological techniques, image analysis, cell culture, genetic and chemical analysis, immunostaining and gene expression.

世界范围内的环境污染正在显著增加，污染物对包括皮肤在内的人类健康的影响日益受到关注。氧化应激的产生是微粒物质和臭氧发挥其有害作用的机制之一。该项目将研究空气污染对人体皮肤功能的生化和生物学影响，以及如何干预这些影响。研究结果将考虑其他外部压力因素，如生活方式和阳光。该项目将受益于纽卡斯尔大学和克罗达欧洲有限公司经验丰富的监督团队。该项目涉及多学科，包括细胞、分子生物学和生理学技术、图像分析、细胞培养、遗传和化学分析、免疫染色和基因表达。

项目成果

Adaptive responses to air pollution in human dermal fibroblasts and their potential roles in aging.

• DOI: 10.1096/fba.2021-00056
• 发表时间: 2021-10
• 期刊: FASEB bioAdvances
• 影响因子: 2.7
• 作者: Reynolds WJ;Bowman A;Hanson PS;Critchley A;Griffiths B;Chavan B;Birch-Machin MA
• 通讯作者: Birch-Machin MA