Forkhead transcription factors in T lymphocytes

T淋巴细胞中的叉头转录因子

• 批准号: 6815681
• 负责人: STANFORD L. PENG
• 金额: $ 34.43万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6815681
• 关键词: T cell receptor; autoimmunity; chromatin immunoprecipitation; flow cytometry; genetically modified animals; helper T lymphocyte; immune response; immune tolerance /unresponsiveness; immunity; immunosuppression; laboratory mouse; leukocyte activation /transformation; microarray technology; northern blottings; nuclear factor kappa beta; polymerase chain reaction; protein structure; transcription factor; western blottings

DESCRIPTION (provided by applicant): The Fox/forkhead family encompasses an ever-growing number of helix-loop-helix transcription factors that participate in diverse biological systems. We describe here an immune role for Foxj1, a Fox family member originally characterized for its role in ciliated epithelial cells. In its absence, helper T (Th) cells are characterized by Th1-skewed hyperproliferation, associated with multi-system auto-inflammation. As such, Foxj1 plays a critical role in the maintenance of T cell quiescence and/or immune tolerance, but we know relatively little about its mechanism of action, as well as its contextual importance in T cell activation. We therefore propose in this application to delve further into the role of Foxj1 in T cell biology - in particular to examine more completely its role in Th proliferation and activation, to determine more fully its relevance to autoimmunity, and to elucidate the molecular pathway in which it operates.

描述（由申请人提供）：Fox/forkhead家族包括参与不同生物系统的越来越多的螺旋-环-螺旋转录因子。我们在这里描述了Foxj 1的免疫作用，Foxj 1是Fox家族成员，最初以其在纤毛上皮细胞中的作用为特征。在其缺失的情况下，辅助性T（Th）细胞的特征在于Th 1偏斜的过度增殖，与多系统自身炎症相关。因此，Foxj 1在维持T细胞静止和/或免疫耐受中起着关键作用，但我们对其作用机制及其在T细胞活化中的重要性知之甚少。因此，我们在本申请中提出进一步深入研究Foxj 1在T细胞生物学中的作用，特别是更全面地检查其在Th增殖和活化中的作用，更全面地确定其与自身免疫的相关性，并阐明其运作的分子途径。