Establishment of a Latrobe Valley power industry cohort and biospecimen bank for the study of asbestos related disease

建立拉特罗布谷电力行业队列和生物样本库以研究石棉相关疾病

• 批准号: nhmrc : 454586
• 负责人: Dr Andrew Holloway
• 金额: $ 40.97万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Strategic Awards
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/establishment-latrobe-valley-related-disease/82284
• 关键词: Establishment; Latrobe; Valley; power; industry

The Latrobe Valley has been the site of Victoria�s electricity generation since the 1920�s. Very large amounts of asbestos were used in the construction of power stations and housing for the workers employed to build and operate them. Asbestos is known to cause a tumour of the lining of the lung cavity called mesothelioma. Mesothelioma is a highly debilitating tumour, with a median survival as low as seven months following diagnosis. Mesothelioma can occur in asbestos exposed individuals up to forty years following exposure, and as such, the peak number of cases of mesothelioma is not expected in Australia for another 10-20 years. The incidence of mesothelioma in the Latrobe Valley is several fold the state average. We will recruit a cohort of 5000 asbestos exposed former power industry workers, and provide information, support and smoking cessation campaigns. For 1000 of the most highly exposed we will offer annual testing for mesothelin, a protein in the blood which may indicate the presence of mesothelioma prior to a clinical diagnosis.

自20世纪20年代以来，拉特罗布山谷一直是维多利亚的发电基地。大量的石棉被用于建造发电站和雇佣来建造和操作发电站的工人的住房。众所周知，石棉会引起一种叫做间皮瘤的肺部肿瘤。间皮瘤是一种高度衰弱的肿瘤，诊断后的中位生存期低至7个月。间皮瘤可在接触石棉长达40年的个体中发生，因此，间皮瘤病例的高峰数预计不会在澳大利亚再过10-20年。拉特罗布山谷的间皮瘤发病率是该州平均水平的几倍。我们将招募5000名接触石棉的前电力工业工人，并提供信息、支持和戒烟运动。对于1000名暴露程度最高的患者，我们将每年进行间皮瘤蛋白检测，这是一种血液中的蛋白质，可以在临床诊断之前提示间皮瘤的存在。