Pulse Doppler Ultrasound Imaging System

脉冲多普勒超声成像系统

• 批准号: 6732563
• 负责人: JOAN F CARROLL
• 金额: $ 27.03万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-15 至 2006-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6732563
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; cardiovascular function; cardiovascular system; echocardiography; ultrasound blood flow measurement

DESCRIPTION (provided by applicant): This proposal requests funding for a state-of-the-art Pulse-Doppler ultrasound echocardiographic instrument, the Philips HDI5000 SonoCT, coupled with the McKesson Horizon Medical Imaging image management system. This system will serve a community of researchers at the University of North Texas Health Science Center (UNTHSC). There is currently one ultrasound instrument at the institution that is available for research work, but it is 9 years old, has limited data reduction capabilities, and does not have the capability to make ultrasound measurements in small animals. The requested ultrasound instrument is mobile which allows ready access to all experimental sites within the HSC, while the image management system will be housed in fixed locations in order to maximize data analysis capabilities. The ultrasound/image management system is a state-of-the-art system, which will enable UNTHSC to meet the current, and future needs of its researchers, as well as modernize teaching technology. It is hoped to take advantage of the broad capabilities of the ultrasound instrument in order to collect data on in vivo structural and functional adaptations of the heart and vasculature to a variety of perturbations, including obesity, hypertension, heart failure, aging, and exercise. Current research needs for the ultrasound/image management system include determining: (i) structural and functional adaptations of the heart in response to blood pressure control and/or exercise training during the development of obesity, (ii) global consequences of pulmonary hypertension and right coronary artery disease, (iii) ventricular remodeling in response to rapid ventficular pacing-induced cardiomyopathy, (iv) the impact of pyruvate therapy on myocardial contractile performance and cerebral perfusion following cardiac arrest and cardiopulmonary resuscitation (v) skeletal muscle vascular conductance and cardiac output to assist in assessing arterial baroreflex and autonomic control of the muscle vasculature at rest and during exercise, and (vi) vagal-cardiac function in the elderly as a result of exercise training.There are six major users from the Department of Integrative Physiology, all with NIH peer reviewed research grants. In addition, we have identified additional departmental users who would benefit from the use of ultrasound echocardiography. Finally, we envision recruiting other Health Science Center researchers in the fields of osteopathic manipulative medicine, clinical medicine, Alzheimer's disease research, and bariatric medicine to take advantage of the instrumentation's capabilities.

描述（由申请人提供）： 该提案要求为最先进的脉冲多普勒超声心动图仪器Philips HDI 5000 SonoCT以及McKesson Horizon医学成像图像管理系统提供资金。该系统将服务于北德克萨斯大学健康科学中心（UNTHSC）的研究人员社区。该机构目前有一台超声仪器可用于研究工作，但它已经使用了9年，数据处理能力有限，不具备对小动物进行超声测量的能力。所要求的超声仪器是移动的，允许随时进入HSC内的所有实验地点，而图像管理系统将被安置在固定位置，以最大限度地提高数据分析能力。超声/图像管理系统是一个最先进的系统，将使联合国人类住区中心能够满足其研究人员目前和未来的需要，并使教学技术现代化。希望利用超声仪器的广泛功能，以收集关于心脏和脉管系统对各种扰动（包括肥胖、高血压、心力衰竭、衰老和运动）的体内结构和功能适应的数据。超声/图像管理系统的当前研究需求包括确定：（i）在肥胖症的发展过程中，心脏响应于血压控制和/或运动训练的结构和功能适应，（ii）肺动脉高压和右冠状动脉疾病的整体后果，（iii）响应于快速心室起搏诱导的心肌病的心室重构，（iv）丙酮酸盐治疗对心脏骤停和心肺复苏后心肌收缩性能和脑灌注的影响（v）骨骼肌血管传导性和心输出量，以帮助评估静息和运动期间的动脉压力感受器反射和肌肉脉管系统的自主控制，和（vi）运动训练对老年人迷走神经-心脏功能的影响。综合生理学系有六个主要用户，他们都获得了NIH同行评审的研究赠款。此外，我们已经确定了其他部门的用户谁将受益于使用超声心动图。最后，我们设想招募其他健康科学中心的研究人员在骨科操作医学，临床医学，阿尔茨海默病研究和减肥医学领域，以利用仪器的能力。