Biomedical Research at the University of Guam

拟议的关岛大学成绩方案的具体目的是为教员提供机会，利用关岛大学的研究设施进行具有生物医学意义的研究，从而改善整体研究环境。UOG SCORE计划有四个目标：1)增加关岛大学教职员工进行生物医学研究的现场能力；2)增加关岛大学教职员工在研究密集型机构进行场外生物医学研究的机会；3)在质量、能力和生产率方面改善关岛大学生物医学研究的研究氛围；4)加强研究与教学和学习之间的联系，使学生能够从增强的研究活动中受益，并能够从他们独特的文化观点为教职员工的生物医学研究努力贡献有价值的观点。该提案包括四个研究项目和一个试点项目。其中两个项目侧重于海洋生物医学研究，并将利用关岛生物多样性的热带海洋环境。研究项目包括1)珊瑚的繁殖生物学和遗传学研究；2)珊瑚礁大型藻类和海绵中具有生物医学活性的天然产物的化学变化；3)在人类肿瘤发生中发挥作用的新的转录调节延长因子；4)氨基和硫基在氢原子中的反应性和二维多核核磁共振方法。参与研究活动的教师将与美国大陆、日本和韩国的科学家互动，并将有机会通过参加校外会议和研究活动以及校园内研讨会和与来访科学家的非正式讨论来学习新技术和新发展。这种经验在关岛这一地理上与世隔绝的地方尤其宝贵。

The specific aim of the proposed University of Guam SCORE Program is to provide opportunities for the faculty to conduct biomedically significant research utilizing the research facilities of the University of Guam, thus enhancing the overall research environment. The UOG SCORE program has four goals: 1) Increase the on-site capacity of University of Guam faculty to do biomedical research; 2) Increase the opportunities for UOG faculty to do biomedical research off-site at research-intensive institutions; 3) improve the research climate at UOG, in the areas of quality, capacity, and productivity, for biomedical research ; and 4) Strengthen the link between research and teaching and learning so that students can benefit from the enhanced research activities and can contribute valuable perspectives from their unique cultural views to the faculty biomedical research endeavors. The proposal includes four research projects and a pilot project. Two of the projects focus on marine biomedical research and will utilize the biologically diverse tropical marine environment of Guam. Research projects include 1) studies of reproductive biology and genetics of corals, 2) chemical variation in biomedically active natural products in coral-reef macroalgae and sponges, 3) novel regulatory transcription elongation factors that play a role in human tumorigenesis, and 4) the reactivity of aminyl and thiyl radicals in hydrogen atom and 2-D multi-nuclear NMR methods. Faculty involved in research activities will interact with scientists in the mainland U.S., Japan, and Korea and will have the opportunity to learn new techniques and developments by participating in off-campus conferences and research activities as well as in on-campus seminars and informal discussions with visiting scientists. Such experiences are especially valuable in the geographically isolated location of Guam.