300 MHz NMR SPECTROMETER

描述(申请人提供)：药物设计和发现领域的研究在很大程度上依赖于用于确定被研究分子的化学结构、构象和在溶液中的动态行为的光谱仪器。目前和在可预见的未来，在开发新的合成药物和从天然来源中分离潜在药物方面，用于评估这些结构特征的最重要的光谱工具之一是核磁共振(核磁共振)谱。俄亥俄州立大学药学院药物化学和生药学系的教职员工、学生和研究人员有着以创造性的方式共享核磁共振光谱仪的悠久传统，以促进国家公认的药物设计和发现研究。这项NCRR共享仪器拨款申请申请资金，用于购买配备7.05特斯拉超导磁体的Bruker Avance 300 FT/核磁共振光谱仪系统、具有X核观测和解耦能力的射频发射器系统、数字采集控制系统、计算机工作站和软件、数字可变温度控制单元和一个5 mm宽带观测探头。所要求的300 MHz核磁共振将取代已有15年历史的250 MHz Bruker AC250光谱仪，后者已成为我们药学院共用仪器设施中处理大量较短持续时间的核磁共振实验的主要仪器。多年来，250 MHz光谱仪为我们提供了异常可靠的服务，但由于零部件供应减少，AC250变得更加过时、不可靠，几乎不可能维修。对于300 MHz核磁共振光谱仪系统的这一要求代表着最具成本效益、能力最强的光谱仪，以满足我们不断增长的本地用户群体的需求，该用户群体约有45人，包括药物化学教员、研究生和博士后研究人员。

DESCRIPTION (provided by applicant): Research in the areas of drug design and discovery relies heavily on spectroscopic instruments used to determine the chemical structure, conformation, and dynamic behavior in solution of the molecules being studied. At present and for the foreseeable future, one of the most important spectroscopic tools used to assess these structural features in the development of new synthetic drugs and the isolation of potential drugs from natural sources is nuclear magnetic resonance (NMR) spectroscopy. The faculty members, students, and research personnel of the Division of Medicinal Chemistry and Pharmacognosy in the College of Pharmacy of The Ohio State University have a long tradition of shared use of NMR spectrometers in creative ways to facilitate nationally recognized research in drug design and discovery. This NCRR Shared Instrumentation grant application requests funds for the purchase of the Bruker Avance 300 FT/NMR spectrometer system with 7.05 Tesla superconducting magnet, rf transmitter system with X-nucleus observe and decouple capabilities, digital acquisition control system, computer workstation and software, digital variable temperature control unit, and a 5 mm broadband observe probe. The requested 300 MHz NMR will replace a 15-year old 250 MHz Bruker AC250 spectrometer that has served as the "workhorse" instrument for handling large numbers of shorter duration NMR experiments in our shared instrument facility in the College of Pharmacy. The 250 MHz spectrometer provided us with unusually reliable service over the years, but the AC250 has become more obsolete, unreliable and nearly impossible to repair due to diminishing parts' availability. This request for a 300 MHz NMR spectrometer system represents the most cost effective, capable spectrometer to accommodate our growing local user group of about 45 individuals, consisting of medicinal chemistry faculty members, graduate students, and post-doctoral researchers.