X-ray area detector system for structural biology

描述(由申请人提供)： 科罗拉多大学医学院将购买Rigaku/MSC R轴IV X射线区域探测器系统，该系统将得到NCRR共享仪器赠款计划的支持和现有霍华德·休斯医学院赠款的资金支持。这种探测器是为了满足UCHSC对数据收集和晶体筛选日益增长的需求而需要的。需求增加的原因是该学院几个系最近扩大了教员，建立了一个新的跨系生物分子结构计划，计划招聘新员工，以及合作结构生物学活动的增加。请求区域探测器系统将通过增加数据收集能力极大地改善现有资源，从而加快下列系统的研究： 基因调控的结构和机制研究(M.丘吉尔) 病毒致癌机制、宿主免疫防御感染(陈晓军) 激素受体作用的结构基础(D.爱德华兹) 多瘤和乳头瘤病毒(R.Garcea)的结构和组装 肌肉收缩和蛋白质设计、结构和稳定性的调节(R.霍奇斯) EB病毒感染与病毒蛋白和补体受体的免疫调节(V.M.Holers) 乙醇作用的结构基础(D·琼斯) DNA聚合酶III的复制机制(C.McHenry) 复制和细胞周期控制的机制(R.Sclafani) 染色质组装和DNA修复(J.泰勒)

DESCRIPTION (provided by applicant): The University of Colorado School of Medicine will purchase a Rigaku/MSC R-AXIS IV++ X-ray area detector system with support from the NCRR Shared Instrumentation Grant program and funds from an existing Howard Hughes Medical Institute grant. This detector is required to meet the growing demand for data collection and crystal screening at UCHSC. The increased demand results from recent expansion of the faculty in several departments in the School, from the establishment of a new interdepartmental Biomolecular Structure Program, from planned new hires, and increased activity in collaborative structural biology. The requested area detector system will vastly improve the existing resources by increasing data collection capacity, thereby accelerating research in the following systems: Structural and mechanistic studies of gene regulation (M. Churchill) Mechanisms of Viral Oncogenesis, Host Immune Defense Against Infection (X.-J. Chen) Structural basis of hormone receptor action (D. Edwards) Structure and assembly of polyoma and papillomaviruses viruses (R. Garcea) Regulation of muscle contraction and protein design, structure and stability (R. Hodges) Epstein-Barr infection and immunoregulation by viral proteins and complement receptors (V. M. Holers) Structural basis of ethanol's actions (D. Jones) Mechanism of DNA polymerase III replication (C. McHenry) Mechanisms of replication and cell-cycle control (R. Sclafani) Chromatin assembly and DNA repair (J. Tyler)