X-ray area detector system for structural biology

描述（由申请人提供）： 科罗拉多医学院将在NCRR共享仪器补助金计划和现有霍华德休斯医学研究所补助金的支持下购买理学/MSC R-AXIS IV++ X射线区域探测器系统。该探测器是为了满足UCHSC日益增长的数据收集和晶体筛选需求。需求的增加是由于最近在学校的几个部门的教师队伍的扩大，从一个新的跨部门生物分子结构计划的建立，从计划的新员工，并在协作结构生物学活动的增加。所要求的区域探测器系统将大大改善现有资源，提高数据收集能力，从而加快对以下系统的研究： 基因调控的结构和机制研究（M。（丘吉尔） 病毒致癌机制，宿主免疫防御感染（X.- J. Chen） 激素受体作用的结构基础（D.爱德华兹） 多瘤病毒和乳头瘤病毒的结构和组装（R。Garcea） 肌肉收缩和蛋白质设计，结构和稳定性的调节（R。霍奇斯） Epstein-Barr感染和病毒蛋白和补体受体的免疫调节（V.M. Holers） 乙醇作用的结构基础（D.琼斯） DNA聚合酶III复制的机制（C.麦克亨利） 复制和细胞周期控制的机制（R。斯克拉法尼） 染色质组装和DNA修复（J.泰勒）

DESCRIPTION (provided by applicant): The University of Colorado School of Medicine will purchase a Rigaku/MSC R-AXIS IV++ X-ray area detector system with support from the NCRR Shared Instrumentation Grant program and funds from an existing Howard Hughes Medical Institute grant. This detector is required to meet the growing demand for data collection and crystal screening at UCHSC. The increased demand results from recent expansion of the faculty in several departments in the School, from the establishment of a new interdepartmental Biomolecular Structure Program, from planned new hires, and increased activity in collaborative structural biology. The requested area detector system will vastly improve the existing resources by increasing data collection capacity, thereby accelerating research in the following systems: Structural and mechanistic studies of gene regulation (M. Churchill) Mechanisms of Viral Oncogenesis, Host Immune Defense Against Infection (X.-J. Chen) Structural basis of hormone receptor action (D. Edwards) Structure and assembly of polyoma and papillomaviruses viruses (R. Garcea) Regulation of muscle contraction and protein design, structure and stability (R. Hodges) Epstein-Barr infection and immunoregulation by viral proteins and complement receptors (V. M. Holers) Structural basis of ethanol's actions (D. Jones) Mechanism of DNA polymerase III replication (C. McHenry) Mechanisms of replication and cell-cycle control (R. Sclafani) Chromatin assembly and DNA repair (J. Tyler)