Core--Developmental Facility

宾夕法尼亚大学-CFAR发展核心的主要目标是通过为试点项目提供资金来源，促进宾夕法尼亚大学、费城儿童医院和维斯塔尔研究所的艾滋病和艾滋病毒相关研究。发展核心将支持艾滋病毒研究新兴领域的短期(1年)项目，包括与招募新调查人员有关的新研究、将注意力转向AII3S的老牌调查人员的研究，以及艾滋病/艾滋病毒调查人员进行的研究，这些研究与他们以前的工作有很大不同。在过去的供资期间，我们总共资助了18个项目，范围从病毒和病毒蛋白的分子分析，到潜在的候选疫苗开发，到对一些非洲社会中性信息传播的社会学分析。这些试点项目中有很大一部分已经转化为全额资助的国家卫生研究院赠款。我们建议在CFAR的第6-10年每年资助5个项目，增加一个专门用于跨学科和/或转化性研究项目的新资助类别。

The major goal of the Penn-CFAR Developmental Core is the promotion of AIDS and HIV-related research at the University of Pennsylvania, the Children's Hospital of Philadelphia, and the Wistar Institute by providing a source of funding for pilot projects. The Developmental Core will support short term (1 year) projects in emerging areas of HIV research, including new research related to the recruitment of new investigators, research by established investigators who are turning their attention to AII3S, and research by AIDS/HIV investigators who are undertaking studies that represent a significant departure from their previous work. During the past funding period, we funded a total of 18 projects ranging in scope from molecular analysis of viruses and virus proteins, through the potential development of vaccine candidates, to sociological analysis of the transmission of sexual information in some African societies. A significant proportion of these pilot projects have been converted into fully funded NIH grants. We are proposing to fund 5 projects each year in years 6-10 of this CFAR, adding a new grant category devoted exclusively to interdisciplinary and/or translational research projects.