CORE--Shared Resources Informatics & Data Management

描述（由申请人提供）：高通量技术，如大规模 测序、DNA表达阵列和高通量蛋白质组学已经爆炸性地增加了数据量以及对数据管理和分析的需求。伯纳姆研究所癌症中心需要有效的信息交流和研究协调，因为它有强大的合作文化和大量的多研究者项目。信息学和数据管理设施提供了所需的资源，以整合信息学和数据管理的研究所一般，特别是癌症药物发现计划，特别是五个设施，严重依赖于信息学（基因分析，蛋白质组学，化学文库筛选，高通量细胞分析设施，以及信息学和数据管理设施本身）。信息学和数据管理设施将提供以下服务：1）数据存储、存档和检索，2）数据分析，3）数据注释、发布和挖掘，4）生物统计学，5）分子建模、结构预测和定制数据库，6）应用程序的安装和维护，以及7）培训。数据库联盟的新兴概念-数据库包装或元数据库-在这种环境中有直接的应用。专用数据库（有些可在因特网上公开获得）是管理、访问和整合数据以及以符合标准和易于使用的方式公布数据的答案。我们建议创建一个研究所范围内的数据管理层，通过一个共同的接口，协调研究所的各种数据密集型项目，增加各种公开资源的数据库联盟的元素。在这一拟议结构的中心概念将是一个？分子页？也就是说，一个数据库记录，包含研究所研究人员所有可用信息（从基因到功能）的链接。至少有两个这样的系统，细胞信号传导联盟的分子页面和结构基因组学联合中心的中央注释数据库，已经在附近的圣地亚哥超级计算机中心开发，直接集成和支持来自伯纳姆教职员工。

DESCRIPTION (provided by applicant): High-throughput technologies such as large scale sequencing, DNA expression arrays, and high throughput proteomics have explosively increased the amount of data and the need for data management and analysis. The Burnham Institute Cancer Center requires effective exchange of information and coordination of research due to its strong collaborative culture and a large number of multi-investigator projects. The Informatics and Data Management Facility provides resources needed to integrate informatics and data management for the Institute in general, for the Cancer Drug Discovery Initiative in particular, and specifically for the five facilities that depend heavily on informatics (Gene Analysis, Proteomics, Chemical Library Screening, High Throughput Cell Analysis Facilities, and the Informatics and Data Management Facility itself). The Informatics and Data Management Facility will provide the following services: 1) Data storage, archiving, and retrieval, 2) Data analysis, 3) Data annotation, publishing, and mining, 4) Biostatistics, 5) Molecular modeling, structure prediction, and custom databases, 6) Installation and maintenance of applications, and 7) Training. Emerging concepts of database confederation - database wrapping or meta-databases - have immediate applications in this environment. Dedicated databases, some publicly available on the Internet, are the answer to managing, accessing and integrating data, and publishing that data in a way that conforms to standards and is readily usable. We propose creating an Institute-wide data management layer that would coordinate various data-intensive projects at the Institute via a common interface, adding elements of database confederation with various publicly available resources. The central concept in this proposed structure would be a ?Molecule page?, i.e., a database record containing links to all of the available information (from gene to function) to Institute researchers. At least two such systems, Molecular Pages at the Alliance for Cell Signaling and central annotation database for the Joint Center for Structural Genomics, have been developed at the nearby San Diego Supercomputer Center, with direct integration and support from the Burnham faculty members.