Imaging Apoptosis to Detect Unstable Atheromatous Plaque
Imaging Apoptosis to Detect Unstable Atheromatous Plaque
批准号:
6686786
负责人:
JAGAT NARULA
金额:
$37.75万
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-01-03 至 2006-11-30
中文摘要
描述(申请人提供):主修冠心病
英文摘要
DESCRIPTION (Provided by Applicant): Coronary artery disease is a major
national health problem with over 13 million patients in the United States Of
these, at least one million people present with acute coronary syndromes
annually and 400,000 die of the acute event. The acute coronary event is
associated with acute thrombosis of the coronary artery and is likely to result
from rupture of the Atherosclerotic plaque. Apoptosis of the neointimal cells
has been proposed as one of the important mechanisms responsible for conversion
of stable coronary plaque to vulnerable plaque and may continue to lead to
plaque rupture. Unlike necrotic cell death, apoptosis is a genetically
programmed process and can be potentially prevented. For such a therapeutic
strategy to become successful, it is necessary to develop techniques for
noninvasive detection of apoptosis in an Atherosclerotic lesion. We have
recently demonstrated that radiolabeled annexin V selectively identifies
surface alterations of apoptotic cells in various myocardial diseases. We,
therefore, reason that annexin V should be able to identify Atherosclerotic
lesions rich in apoptotic cells. Our preliminary studies have demonstrated the
feasibility of annexin imaging in experimental Atherosclerotic lesions induced
in rabbit aorta. The radiotracer uptake was seen only in lesions with abundant
apoptotic neointimal cells, predominantly in the apoptotic macrophages. We
propose to evaluate the potential role of annexin imaging in the detection of
vulnerable plaque. The evaluation will be performed serially in different
animal models and finally in a pilot clinical trial. We will first confirm the
feasibility of annexin imaging in experimentally induced Atherosclerotic aortic
lesions in rabbits and carefully correlate radiolabeled annexin V uptake with
the histologic characteristics of the plaque and apoptotic index. In the next
step, annexin imaging will be performed in a porcine model for the detection of
coronary Atherosclerotic lesions. Subsequently, cellular site of annexin uptake
will be precisely characterized in genetically altered rodent models, which
demonstrate advanced Atherosclerotic lesions closet to human coronary
pathology. Finally, annexin imaging will be performed in a pilot clinical study
in patients undergoing carotid endarterectomy. The impending surgical
intervention will allow histopathological evaluation of the endarterectomy
specimens to define potential utility of annexin imaging.
期刊论文(9)
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Broad and specific caspase inhibitor-induced acute repression of apoptosis in atherosclerotic lesions evaluated by radiolabeled annexin A5 imaging.
通过放射性标记的膜联蛋白 A5 成像评估广泛且特异性的 caspase 抑制剂诱导的动脉粥样硬化病变细胞凋亡的急性抑制。
DOI:
10.1016/j.jacc.2007.08.044
发表时间:
2007
期刊:
Journal of the American College of Cardiology
影响因子:
24
作者:
[Sarai,Masayoshi, Hartung,Dagmar, Petrov,Artiom, Zhou,Jun, Narula,Navneet, Hofstra,Leo, Kolodgie,Frank, Isobe,Satoshi, Fujimoto,Shinichiro, Vanderheyden,Jean-Luc, Virmani,Renu, Reutelingsperger,Chris, Wong,NathanD, Gupta,Sudhir, Narula,Jaga]
通讯作者:
Narula,Jaga
Noninvasive imaging of atherosclerotic lesions in apolipoprotein E-deficient and low-density-lipoprotein receptor-deficient mice with annexin A5.
使用膜联蛋白 A5 对载脂蛋白 E 缺陷和低密度脂蛋白受体缺陷小鼠的动脉粥样硬化病变进行无创成像。
DOI:
--
发表时间:
2006
期刊:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子:
--
作者:
[Isobe,Satoshi, Tsimikas,Sotirios, Zhou,Jun, Fujimoto,Shinichiro, Sarai,Masayoshi, Branks,MichaelJ, Fujimoto,Ai, Hofstra,Leonard, Reutelingsperger,ChrisP, Murohara,Toyoaki, Virmani,Renu, Kolodgie,FrankD, Narula,Navneet, Petrov,Artiom, Naru]
通讯作者:
Naru
How to identify the asymptomatic high-risk patient?
如何识别无症状高危患者?
DOI:
10.1016/j.cpcardiol.2009.07.001
发表时间:
2009
期刊:
Current problems in cardiology
影响因子:
4.2
作者:
[Schuijf,JoanneD, Achenbach,Stephan, Zoghbi,WilliamA, Boersma,Eric, Raggi,Paolo, Weber,Michael, Nagel,Eike, Narula,Jagat, Wackers,FransJTh, Poldermans,Don, Bax,JeroenJ]
通讯作者:
Bax,JeroenJ
99mTc-annexin V imaging for in vivo detection of atherosclerotic lesions in porcine coronary arteries.
99mTc-annexin V 成像用于猪冠状动脉动脉粥样硬化病变的体内检测。
DOI:
--
发表时间:
2005
期刊:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子:
--
作者:
[Johnson,LynneL, Schofield,Lorraine, Donahay,Tammy, Narula,Navneet, Narula,Jagat]
通讯作者:
Narula,Jagat
Resolution of apoptosis in atherosclerotic plaque by dietary modification and statin therapy.
通过饮食调整和他汀类药物治疗解决动脉粥样硬化斑块中的细胞凋亡。
DOI:
--
发表时间:
2005
期刊:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子:
--
作者:
[Hartung,Dagmar, Sarai,Masayoshi, Petrov,Artiom, Kolodgie,Frank, Narula,Navneet, Verjans,Johan, Virmani,Renu, Reutelingsperger,Chris, Hofstra,Leo, Narula,Jagat]
通讯作者:
Narula,Jagat
Mechanistic registry to study whether infection with Corona Virus Disease 2019 (COVID-19) accelerates atherosclerotic plaque progression
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批准号:10482402
-
项目类别:
-
资助金额:$148.67万
-
财政年份:2022
-
负责人:JAGAT NARULA
-
依托单位:
Mechanistic registry to study whether infection with Corona Virus Disease 2019 (COVID-19) accelerates atherosclerotic plaque progression
-
批准号:10558896
-
项目类别:
-
资助金额:$150.63万
-
财政年份:2022
-
负责人:JAGAT NARULA
-
依托单位:
Mechanistic registry to study whether infection with Corona Virus Disease 2019 (COVID-19) alters atherosclerotic plaque progression
-
批准号:10280423
-
项目类别:
-
资助金额:$162.06万
-
财政年份:2021
-
负责人:JAGAT NARULA
-
依托单位:
Targeting MMPS to Image Atherosclerosis
-
批准号:6950782
-
项目类别:
-
资助金额:$35.07万
-
财政年份:2004
-
负责人:JAGAT NARULA
-
依托单位:
Targeting MMPS to Image Atherosclerosis
-
批准号:6848199
-
项目类别:
-
资助金额:$36.24万
-
财政年份:2004
-
负责人:JAGAT NARULA
-
依托单位:
Targeting MMPS to Image Atherosclerosis
-
批准号:7269390
-
项目类别:
-
资助金额:$33.21万
-
财政年份:2004
-
负责人:JAGAT NARULA
-
依托单位:
Targeting MMPS to Image Atherosclerosis
-
批准号:7117641
-
项目类别:
-
资助金额:$34.22万
-
财政年份:2004
-
负责人:JAGAT NARULA
-
依托单位:
Imaging Apoptosis to Detect Unstable Atheromatous Plaque
-
批准号:6418408
-
项目类别:
-
资助金额:$37.35万
-
财政年份:2002
-
负责人:JAGAT NARULA
-
依托单位:
Imaging Apoptosis to Detect Unstable Atheromatous Plaque
-
批准号:6620504
-
项目类别:
-
资助金额:$36.48万
-
财政年份:2002
-
负责人:JAGAT NARULA
-
依托单位:
国内基金
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批准号:81273459
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项目类别:面上项目
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资助金额:60.0万元
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批准年份:2012
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负责人:沙先谊
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依托单位: