Innovative Membrane Protein Tech: Sample Preparation IMP

创新膜蛋白技术：样品制备 IMP

• 批准号: 6962232
• 负责人: GEOFFREY A CHANG
• 金额: $ 35.4万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-24 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6962232
• 关键词: biomedical automation; biotechnology; chemical stability; functional /structural genomics; lipid structure; lipids; membrane proteins; method development; nanotechnology; peptide chemical synthesis; sample collection; small molecule; structural biology; synthetic protein; technology /technique development

Aim 2. Develop novel methods and sample preparation reagents and tools for the stabilization of IMPs for structural biology studies. a. Lipid Chemistry - develop novel small molecule and polymeric compounds that extract and stabilize IMPs. b. Protein Stabilization Reagents - develop novel protein stabilization reagents (e.g. antibodies, rafts) that can be used to stabilize IMP preparations. c. Nanofabrication - develop novel tools to grow or analyze IMP samples using nanofabrication tools.

目标2.开发新的方法和样品制备试剂和工具，用于稳定结构生物学研究中的IMP。 a. 脂质化学-开发新型小分子和聚合物化合物，用于提取和稳定IMP。 B. 蛋白质稳定试剂-开发可用于稳定IMP制剂的新型蛋白质稳定试剂（例如抗体、筏）。 C. 纳米纤维-开发新的工具，使用纳米纤维工具生长或分析IMP样品。