BIOSTATISTICS & BIOINFORMATICS CORE

UNC GI癌症孢子生物统计学和生物信息学核心是由UNC Lineberger综合癌症中心的最新核心资源开发的。在教师招聘方面的大幅扩张，重点是基因分析，以及对硬件和相关数据库的投资，使该中心准备启动一个集成但扩展的核心资源，以支持GI孢子项目。高级教员乔·易卜拉欣和弗雷德·赖特将为这一核心提供新的智力领导。他们在生物统计学、统计遗传学的新领域、与临床研究的整合以及癌症中心项目的转化研究方面都有丰富的经验。除了扩大领导力，

The UNC GI Cancer SPORE Biostatistics and Bioinformatics Core was developed from the newest core resources at the UNC Lineberger Comprehensive Cancer Center. Substantial expansion in faculty recruitment, with an emphasis on genetic analysis, and an investment in hardware and associated databases has prepared the Center to launch an integrated yet expanded core resource to support the GI SPORE projects. Senior faculty recruits Joe Ibrahim and Fred Wright will provide new intellectual leadership for this core. Both have substantial experience in biostatistics, new areas of statistical genetics, integration with clinical research, and Cancer Center programs for translational research. In addition to expanded leadership, involvement from the Departments of Statistics and Biostatistics have expanded the Cancer Center's and thus the UNC GI Cancer SPORE's capabilities in this area. A substantial investment in databases to store gene expression microarray data from multiple platforms and to import data from other institutions is already leading to productive translational research at the Cancer Center. Continued development of parallel clinical and epidemiologic databases for clinical trials and population-based data will be linked to our microarray databases via an honest broker model that will be overseen by the GI SPORE and the UNC Lineberger Biostatistic cores. The five projects in the GI SPORE present interesting challenges, both as translational research and as biostatistical/bioinformatics problems. Complementary skills possessed by the Core faculty will lead to new approaches to gene expression data as well as cross-platform analysis. Input from the Core Directors and other members of this core is described within both the project write-ups and in this section. Top-notch senior and promising junior faculty, an emphasis on translational and genetic research at the Cancer Center, and continuing investment in data management will provide an excellent resource for the UNC GI Cancer SPORE's projects with large data sets. The Core will provide appropriate input into design, management, and analysis as the most promising lines of translational research are pursued.