BIOSTATISTICS & BIOINFORMATICS CORE

生物统计学

• 批准号: 6791857
• 负责人: JOSEPH G IBRAHIM
• 金额: $ 16.79万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6791857
• 关键词: bioinformatics; biomedical facility; data management; neoplasm /cancer genetics; statistics /biometry

The UNC GI Cancer SPORE Biostatistics and Bioinformatics Core was developed from the newest core resources at the UNC Lineberger Comprehensive Cancer Center. Substantial expansion in faculty recruitment, with an emphasis on genetic analysis, and an investment in hardware and associated databases has prepared the Center to launch an integrated yet expanded core resource to support the GI SPORE projects. Senior faculty recruits Joe Ibrahim and Fred Wright will provide new intellectual leadership for this core. Both have substantial experience in biostatistics, new areas of statistical genetics, integration with clinical research, and Cancer Center programs for translational research. In addition to expanded leadership, involvement from the Departments of Statistics and Biostatistics have expanded the Cancer Center's and thus the UNC GI Cancer SPORE's capabilities in this area. A substantial investment in databases to store gene expression microarray data from multiple platforms and to import data from other institutions is already leading to productive translational research at the Cancer Center. Continued development of parallel clinical and epidemiologic databases for clinical trials and population-based data will be linked to our microarray databases via an honest broker model that will be overseen by the GI SPORE and the UNC Lineberger Biostatistic cores. The five projects in the GI SPORE present interesting challenges, both as translational research and as biostatistical/bioinformatics problems. Complementary skills possessed by the Core faculty will lead to new approaches to gene expression data as well as cross-platform analysis. Input from the Core Directors and other members of this core is described within both the project write-ups and in this section. Top-notch senior and promising junior faculty, an emphasis on translational and genetic research at the Cancer Center, and continuing investment in data management will provide an excellent resource for the UNC GI Cancer SPORE's projects with large data sets. The Core will provide appropriate input into design, management, and analysis as the most promising lines of translational research are pursued.

生物统计学和生物信息学核心是从最新的核心资源开发的，在林伯格综合癌症中心。在教师招聘的大幅扩张，重点是遗传分析，并在硬件和相关数据库的投资准备中心推出一个集成的，但扩大的核心资源，以支持GI孢子项目。高级教师招聘乔·易卜拉欣和弗雷德·赖特将为这一核心提供新的智力领导。两人都在生物统计学、统计遗传学的新领域、与临床研究的整合以及癌症中心的转化研究项目方面拥有丰富的经验。除了扩大领导能力外， 统计和生物统计部门的参与扩大了癌症中心的能力，从而扩大了癌症中心在这一领域的能力。对数据库进行大量投资，以存储来自多个平台的基因表达微阵列数据并从其他机构导入数据，这已经导致癌症中心进行了富有成效的转化研究。临床试验和基于人群的数据的并行临床和流行病学数据库的持续开发将通过诚实经纪人模型与我们的微阵列数据库链接，该模型将由GI SPORE和UNC Lineberger生物统计核心监督。GI SPORE中的五个项目提出了有趣的挑战，无论是作为转化研究还是作为 生物统计学/生物信息学问题。核心教师拥有的补充技能将导致基因表达数据的新方法以及跨平台分析。核心主管和该核心的其他成员的意见在项目报告和本节中均有描述。一流的高级和有前途的初级教师，在癌症中心的转化和遗传研究的重点，并在数据管理方面的持续投资将提供一个很好的资源，为癌症中心的项目与大型数据集。核心将提供适当的输入到设计，管理和分析，因为最有前途的线的转化研究的追求。