CORE --MOLECULAR

核心——分子

• 批准号: 6844656
• 负责人: Kenneth Robert WILLIAMS
• 金额: $ 3.86万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6844656
• 关键词: bioinformatics; biomedical facility; biotechnology; clinical research; genetic mapping; genetic techniques; genotype; human genetic material tag; linkage mapping; microarray technology; nucleic acid chemical synthesis; nucleic acid sequence

Specific Aim. Many tasks in molecular biology and genetics involve repetitive processes or assays. The performance of many of these is best accomplished with specialized instrumentation and dedicated staff in a core facility. In the context of the Yale SCOR in Hypertension, there are a number of such bench tasks and analysis tools that benefit from such core facilities. The Specific Aim of the Molecular Core is to provide infrastructure support for the following activities. 1. Oligonucleotide synthesis 2. DNA sequencing 3. Microsatellite genotyping 4. SNP identification and genotyping 5. Preparation and archiving of genomic DNA 6. Analysis of linkage and association 7. Bioinformatics

具体目标。分子生物学和遗传学中的许多任务涉及重复的过程或测定。其中许多的性能是最好的完成与专门的仪器和专门的工作人员在一个核心设施。在耶鲁大学高血压SCOR的背景下，有一些这样的实验室任务和分析工具，受益于这样的核心设施。分子核心的具体目标是为以下活动提供基础设施支持。1.寡核苷酸合成2. DNA测序3.微卫星基因分型4. SNP鉴定和基因分型5.基因组DNA的制备和存档6. 7、关联分析。生物信息