Psychiatric Disorders /HIV Interface in Women in Congo

描述（申请人提供）：北卡罗来纳州公共卫生学院（公共卫生学院）、约翰霍普金斯大学医学院（约翰霍普金斯大学）和鲁汶天主教大学社会和文化人类学系非洲研究中心，比利时建议加强撒哈拉以南非洲社会科学教学和研究中心（CERDAS）的精神疾病研究能力，金沙萨公共卫生学院，金沙萨大学，刚果。 这一多步骤的研究和能力建设进程将通过扩大/加强现有的CERDAS/KSPH伙伴关系与卫生部，JHU和CU进行。 我们的初步努力将侧重于：1）在大量孕妇及其核心家庭中观察到的艾滋病毒感染事件和流行病例之间的相互作用，我们目前在金沙萨（人口约900万）最大的产妇，位于恩吉利（人口约200万）的Kingasani产妇（KM）（每年分娩人数约10 000人）中进行了跟踪。 恩吉利也将是我们以社区为基础的（CB）PD研究的地点。 2)在同一KM人群中产后抑郁症（PND）的发病率和后果。 我们的研究将是CB。 PD经常被污名化。 CEDRAS/CU在Ndjili进行了15年以上的实地研究，传统治疗师在与西方设施不接触的“隐藏”当地治疗场所护理PD患者。 我们的团队与这些当地的治疗师有着可靠/有效的联系。 基于我们在KM/Ndjili的研究，将进一步促进我们深入目标社区的努力，以“发掘”PD患者，否则这些患者将无法计数（在epi研究中很重要），无法诊断和治疗。 我们打算利用现有的基础设施，在我们的高度有效的预防母婴艾滋病毒传播干预计划在KM研究PD和PND在我们的人口。 在R24赠款，我们将首先确定短期研究的重要领域，并分配KSPH MPH学者医生进行精心指导的研究。 精心挑选的脑障碍研究员（BDF）将在鲁汶巴尔的摩/查佩尔山接受12个月的指导培训。 回到金沙萨，BDF将获得额外研究项目的再入学赠款，以通知我们的R 01补助金准备。 所有合作者定期在金沙萨举行会议，这将使我们能够共同准备有竞争力的R 01赠款。

DESCRIPTION (provided by applicant): University of North Carolina's School of Public Health (UNC), Johns Hopkins University's School of Medicine (JHU) and the African Studies Center, Department of Social and Cultural Anthropology, Catholic University (CU), Leuven, Belgium propose to strengthen the psychiatric disorders (PD) research capacity of the Center for Teaching and Research in Social Science for sub-Saharan Africa (CERDAS)/Kinshasa School of Public Health (KSPH), University of Kinshasa in Kinshasa, Congo. This multi-step research and capacity building process will occur through expansion/reinforcement of the existing CERDAS/KSPH partnership with UNC, JHU and CU. Our initial efforts will focus on: 1) The interplay between PD and incident and prevalent cases of HIV infection observed in large cohorts of pregnant women and their nuclear families we currently follow in Kinshasa's (population approximately 9 million) largest maternity, Kingasani Maternity (KM) (annual number of deliveries approximately 10,000) located in Ndjili (population approximately 2 million). Ndjili will also be the site for our community-based (CB) PD research. 2) The incidence and consequences of postnatal depression (PND) in this same KM population. Our studies will be CB. PD is often stigmatizing. CEDRAS/CU has conducted field research in Ndjili for 15+ years with traditional healers caring for patients with PD who sock treatment at "hidden" local healing sites operating out of contact with Western-orientated facilities. Our group has solid credible/effective contact with these local healers. Basing our studies at KM/Ndjili will further facilitate our efforts to reach into the target community to "unearth" patients with PD who would otherwise remain unenumerated (important in epi studies), undiagnosed and untreated. We intend to use the existing infrastructure at our highly effective prevention of mother to child HIV transmission intervention program at KM to study PD and PND in our population. In the R24 grant we will first identify essential areas for short-term research and assign KSPH MPH scholar physicians to conduct carefully mentored research. Carefully selected Brain Disorder Fellows (BDF) will receive 12 months mentored training in Leuven Baltimore/Chapel Hill. Returning to Kinshasa, BDF will receive re-entry grants for additional research projects to inform our R01 grant preparation. Periodic meetings in Kinshasa among all collaborators will enable us to collectively prepare a competitive R01 grant.