Spectroscopic Polarized-Light-Based Laparoscopy

描述（由申请人提供）： 我们建议在腹腔镜检查中提高子宫内膜病变的可见性。具体而言，我们提出了一个腹腔镜系统，其中入射光和检测光的偏振控制的发展。问题是子宫内膜异位症很难在非侵入性和腹腔镜检查中诊断。目视检查和疑似病变的组织学确认之间的相关性从未超过65%。我们建议采取从内部组织结构反射的光的测量，从而获得偏振的二维映射，并允许病变的结缔组织基质和周围正常组织之间存在的差异的可视化。所提出的解决方案利用了组织光学中的几个关键概念，用于开发基于腹腔镜的新型系统。我们将在动物模型中测试该系统的安全性和有效性，之后将根据需要对该系统进行改进。该系统在人体中的测试是子宫内膜异位症的最佳模型，将进行测试以证明安全性，有效性，并为进一步的设备改进提供数据。

DESCRIPTION (provided by applicant): We propose to improve the visibility of endometrial lesions during laparoscopy. Specifically, we propose the development of a laparoscopic system in which the polarization of the incident and detected light is controlled. The problem is that endometriosis is difficult to diagnose both noninvasively and during laparoscopy. The documented correlation between visual inspection and histological confirmation of suspected lesions is never higher than 65%. We propose to take measurements of light reflected from internal tissue structures thereby obtaining a two-dimensional mapping of the polarization and allowing visualization of the differences that exists between the connective tissue matrix of the lesions and the surrounding normal tissue. The proposed solution takes advantage of several key concepts in tissue optics for the development of a novel laparascope-based system. We will test the safety and efficacy of the system in an animal model, after which the system will be refined as needed. Testing of the system in humans, which is the best model for endometriosis, will be done to demonstrate safety, efficiacy, and provide data for further device improvements.