Spectroscopic Polarized-Light-Based Laparoscopy

描述(由申请人提供)： 我们建议在腹腔镜术中提高子宫内膜病变的可见度。具体地说，我们建议开发一种可以控制入射和被检测光的偏振的腹腔镜系统。问题是子宫内膜异位症无论是在非侵入性还是在腹腔镜检查中都很难诊断。可疑病变的目视检查和组织学确认之间的记录相关性从来不高于65%。我们建议测量从内部组织结构反射的光，从而获得偏振态的二维映射，并允许可视化病变结缔组织基质与周围正常组织之间存在的差异。提出的解决方案利用了组织光学中的几个关键概念来开发一种新的基于腹腔镜的系统。我们将在动物模型中测试该系统的安全性和有效性，之后将根据需要对该系统进行改进。该系统是治疗子宫内膜异位症的最佳模型，将在人体上进行测试，以证明其安全性、有效性，并为进一步改进设备提供数据。

DESCRIPTION (provided by applicant): We propose to improve the visibility of endometrial lesions during laparoscopy. Specifically, we propose the development of a laparoscopic system in which the polarization of the incident and detected light is controlled. The problem is that endometriosis is difficult to diagnose both noninvasively and during laparoscopy. The documented correlation between visual inspection and histological confirmation of suspected lesions is never higher than 65%. We propose to take measurements of light reflected from internal tissue structures thereby obtaining a two-dimensional mapping of the polarization and allowing visualization of the differences that exists between the connective tissue matrix of the lesions and the surrounding normal tissue. The proposed solution takes advantage of several key concepts in tissue optics for the development of a novel laparascope-based system. We will test the safety and efficacy of the system in an animal model, after which the system will be refined as needed. Testing of the system in humans, which is the best model for endometriosis, will be done to demonstrate safety, efficiacy, and provide data for further device improvements.