Spectroscopic Polarized-Light-Based Laparoscopy

基于光谱偏振光的腹腔镜检查

• 批准号: 6728127
• 负责人: JOSEPH T WALSH
• 金额: $ 26.29万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6728127
• 关键词: clinical research; diagnosis design /evaluation; dogs; endometriosis; female; human subject; image processing; laparoscopy; optics; patient oriented research; reproductive system disorder diagnosis; technology /technique development; women' s health

DESCRIPTION (provided by applicant): We propose to improve the visibility of endometrial lesions during laparoscopy. Specifically, we propose the development of a laparoscopic system in which the polarization of the incident and detected light is controlled. The problem is that endometriosis is difficult to diagnose both noninvasively and during laparoscopy. The documented correlation between visual inspection and histological confirmation of suspected lesions is never higher than 65%. We propose to take measurements of light reflected from internal tissue structures thereby obtaining a two-dimensional mapping of the polarization and allowing visualization of the differences that exists between the connective tissue matrix of the lesions and the surrounding normal tissue. The proposed solution takes advantage of several key concepts in tissue optics for the development of a novel laparascope-based system. We will test the safety and efficacy of the system in an animal model, after which the system will be refined as needed. Testing of the system in humans, which is the best model for endometriosis, will be done to demonstrate safety, efficiacy, and provide data for further device improvements.

描述（由申请人提供）： 我们建议在腹腔镜检查过程中提高子宫内膜病变的可见性。具体而言，我们提出了腹腔镜系统的发展，其中控制了事件和检测到的光的极化。问题在于，子宫内膜异位症很难在腹腔镜检查过程中和腹腔镜检查过程中诊断。可疑病变的视觉检查与组织学确认之间的相关性永远不会高于65％。我们建议对内部组织结构反射的光进行测量，从而获得极化的二维映射，并允许可视化病变的结缔组织基质与周围正常组织之间存在的差异。所提出的解决方案利用了组织光学元件中的几个关键概念，开发了一种新型的基于laparascope的系统。我们将在动物模型中测试系统的安全性和功效，之后将根据需要进行完善系统。将对人类的系统进行测试，这是子宫内膜异位症的最佳模型，以证明安全性，有效性，并提供数据以进一步改进设备。