Understanding Neuroplasticity Induced by TrYptamines (UNITY)

了解色胺诱导的神经可塑性 (UNITY)

• 批准号: 2396688
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2396688
• 关键词: Understanding; Neuroplasticity; Induced; TrYptamines; UNITY

Serotonergic psychedelics have broad therapeutic potential as a novel psychiatricintervention across a range of disorders. They also promote mental wellbeing in 'healthy'people. Despite these demonstrations, we have little insight into the mechanisms oftherapeutic change following psychedelics. A likely candidate is neural plasticity though therehave been few direct tests. This project examines changes in the network organization of thehuman brain after a single administration of dimethyltryptamine (DMT) using functionalmagnetic resonance imaging (fMRI). Network measures will be used to predict clinicallyrelevant benefits in heavy drinkers and improvements in well-being in typical populations.

5-羟色胺能致幻剂作为一种新的精神干预手段，在一系列疾病中具有广泛的治疗潜力。他们还促进“健康”人的心理健康。尽管有这些证明，我们对致幻剂治疗变化的机制知之甚少。一个可能的候选者是神经可塑性，尽管很少有直接的测试。本项目利用功能性磁共振成像（fMRI）研究了二甲基色胺（DMT）单次给药后人脑网络组织的变化。网络测量将用于预测重度饮酒者的临床相关益处和典型人群的幸福感改善。