Exploring the switch between mesenchymal and ameboid cancer cell migration using microfluidics and MATLAB based analysis of live cell imaging

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Metastasis is the primary cause of cancer related deaths. Crucially, any potential treatmentof metastasis, which may target increased migration, needs to take into account that cancercell migration is plastic, i.e. that cancer cells can easily switch between a mesenchymal and acontractility driven amoeboid migration mode. The latter mode can be induced by confiningcells. However, it is not known how cancer cells can actively switch between these twomodes. In this project, you will explore a novel mechanosensor that may act as aphysiological switch between mesenchymal and amoeboid 3D cancer cell migration.