Minority Predoctoral Fellowship Program

少数族裔博士前奖学金计划

• 批准号: 6892591
• 负责人: Ryan Mark Lauchli
• 金额: $ 2.99万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-14 至 2007-09-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6892591
• 关键词: Diels Alder reaction; allyl compound; chemical bond; chemical synthesis; predoctoral investigator; stereochemistry; technology /technique development

DESCRIPTION (provided by applicant): Allylsilanes have become indispensable in synthesis as reactants in carbon-carbon bond forming transformations. Bridgehead allylsilanes are a recent but un-studied sub-class of these important intermediates. The proposal includes an outline for investigating the carbon-carbon bond forming reactions of bridgehead allylsilanes. The novel stereoelectronic environment of these compounds will be utilized to direct electrophiles in asymmetric reactions. The mechanistic knowledge gained through these investigations will expand upon current understanding of allylsilane reactivity. Additionally, a demonstration of the utility of bridgehead allylsilanes in synthesis will be pursued in an approach to the natural product, Upial.

描述（由申请人提供）：烯丙基硅烷作为碳-碳键形成转化的反应物在合成中是不可或缺的。桥头堡烯丙硅烷是这些重要中间体中最近发现但尚未研究的亚类。该建议包括研究桥头堡烯基硅烷碳-碳成键反应的大纲。这些化合物的新型立体电子环境将用于指导不对称反应中的亲电试剂。通过这些研究获得的机械知识将扩展到目前对烯丙基硅烷反应性的理解。此外，桥头堡烯丙硅烷在合成中的应用将在天然产物Upial的方法中进行演示。