Determining the origins of Candida auris from experimental, epidemiological and ecological investigations

通过实验、流行病学和生态调查确定耳念珠菌的起源

• 批准号: 2399257
• 金额: --
• 依托单位: UNIVERSITY OF EXETER
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2399257
• 关键词: Determining; origins; Candida; auris; experimental

Fungi are a growing threat to the health of humans. Many fungal diseases of humans are also becoming increasingly difficult to treat with antifungals as pathogens evolve resistance. Candida auris has recently emerged as a multidrug-resistant pathogen of humans that causes severe illness in hospitalised patients. Genetic studies have confirmed C. auris includes as many as five genetically divergent populations. However, it is unknown when and where C. auris evolved, and what ecological niche(s) it occupied before 'spilling over' in to human populations. Using a combination of experimental and phylogenetic approaches, this project seeks to answer the evolutionary origins of C. auris. The closest relatives of C. auris have been found in fish, suggesting the clade may have evolved in an aquatic environment, possibly as a coloniser or pathogen of other fish. Furthermore, C. auris is able to grow at very high temperates and in high salt concentrations. The project will explore ancestral and evolutionary history from whole genome sequence data, as well as the ability of C. auris to colonise the eggs and embryos of Killifish: a new experimental system developed at the University of Exeter that focusses on a species naturally found in shallow warm subtropical and tropical waters.

真菌对人类健康的威胁越来越大。随着病原体产生耐药性，人类的许多真菌疾病也越来越难以用抗真菌药物治疗。耳念珠菌最近成为一种耐多药的人类病原体，导致住院患者严重疾病。遗传学研究证实了C。奥里斯包括多达五个遗传上不同的种群。然而，它是未知的何时何地C。耳的进化，以及它在“溢出”到人类种群之前占据了什么样的生态位。本研究结合实验和系统发育的方法，试图回答C.耳。C.的近亲。在鱼类中发现了耳虫，这表明该分支可能是在水生环境中进化的，可能是作为其他鱼类的殖民者或病原体。此外，C. Auris能够在非常高的温度和高盐浓度下生长。该项目将从全基因组序列数据中探索祖先和进化历史，以及C。auris来殖民刺鱼的卵和胚胎：埃克塞特大学开发的一个新的实验系统，专注于在浅温暖的亚热带和热带沃茨中自然发现的一个物种。

项目成果

Population genetics and microevolution of clinical Candida glabrata reveals recombinant sequence types and hyper-variation within mitochondrial genomes, virulence genes, and drug targets.

• DOI: 10.1093/genetics/iyac031
• 发表时间: 2022-05-05
• 期刊: GENETICS
• 影响因子: 3.3
• 作者: Helmstetter, Nicolas;Chybowska, Aleksandra D.;Delaney, Christopher;Dantas, Alessandra Da Silva;Gifford, Hugh;Wacker, Theresa;Munro, Carol;Warris, Adilia;Jones, Brian;Cuomo, Christina A.;Wilson, Duncan;Ramage, Gordon;Farrer, Rhys A.
• 通讯作者: Farrer, Rhys A.