Early life antecedents of adult chronic disease

描述(由申请人提供)：以前被认为只发生在成年人身上的疾病越来越多地在年轻人中被诊断出来。许多成人慢性疾病的亚临床先兆，如心血管疾病和2型糖尿病，起源于儿童和青春期。在早期生活中测量的慢性病风险因素--儿童期、青春期和青壮年--反映了影响成人慢性病发展的潜在生物机制。与这些风险模式相关的因素，如身体成分、性成熟、体力活动和其他传统的心血管疾病风险因素，将被调查。因此，这项研究的总体目标是确定对以后疾病结果的早期预测因素。这一目标将使用莱特州立大学医学院寿命健康研究中心的FELS纵向研究参与者提供的广泛的长期系列数据来解决。拟议的研究目标将通过追求几个具体的研究问题来实现。这些问题的重点是确定在儿童和青春期测量的疾病风险因素在多大程度上可以预测个人的成年结果。要考虑的危险因素包括身体成分、胰岛素抵抗、性成熟、血压、血脂、体力活动、健康史和生活方式因素。该项目的完成将为心血管疾病和2型糖尿病高危人群早期发现亚临床疾病提供重要的新信息。

DESCRIPTION (provided by applicant): Diseases previously considered to occur exclusively in adults are increasingly diagnosed in younger adults. Many of the subclinical antecedents of adult chronic diseases such as cardiovascular disease and type 2 diabetes originate in childhood and adolescence. Chronic disease risk factors measured in early life--childhood, adolescence, and young adulthood--reflect the underlying biological mechanisms that influence the development of adult chronic disease. Factors associated with these risk patterns, such as aspects of body composition, sexual maturation, physical activity and other traditional cardiovascular disease risk factors, will be investigated. Thus, the general aim of the study is to identify early predictors of later disease outcomes. This aim will be addressed using the extensive long term serial data from the participants in the Fels Longitudinal Study based at the Lifespan Health Research Center, Wright State University School of Medicine. The proposed study objectives will be accomplished by pursuing several specific research questions. These questions focus on determining the extent to which disease risk factors measured in childhood and adolescence are predictive in individuals of adult outcomes. Risk factors to be considered include body composition, insulin resistance, sexual maturation, blood pressure, lipid profiles, physical activity, health history, and lifestyle factors. Completion of this project will yield important new information regarding early detection of subclinical disease in those at risk for cardiovascular disease and type 2 diabetes.