Acute Alcohol and Nicotine Interactions in Men and Women

描述（由申请方提供）：拟定研究的目的是研究尼古丁与饮酒之间的关系。一些研究已经建立了吸烟和饮酒之间的强正相关，但这种关联背后的确切机制尚不清楚。此外，很少有研究对样本进行分层，以检查酒精和烟草之间联系的性别差异。第一个目标是检查急性酒精消费是否以剂量和BAC肢体依赖的方式增加香烟渴望，并检查男性是否比女性对酒精诱导的香烟渴望更敏感。虽然研究已经检查了饮酒对伴随的吸烟或渴望的影响，但很少有研究检查反向途径（即，尼古丁对饮酒的影响）。因此，第二个目标是确定尼古丁暴露是否会增加酒精渴望和消费，并检查这种反应的性别差异。 了解男性和女性酒精和尼古丁相互作用的潜在独特生物行为机制可能有助于专门针对性别制定早期预防和治疗方案。

DESCRIPTION (provided by applicant): The purpose of the proposed studies is to investigate the relationships between nicotine and alcohol consumption. Several studies have established a strong positive association between cigarette smoking and alcohol use, but the exact mechanisms underlying this association are unknown. Also, few studies have stratified their samples to examine gender differences in the link between alcohol and tobacco. The first goal is to examine whether acute alcohol consumption increases cigarette craving in a dose and BAC-limb dependent manner, and to examine if men show more sensitivity to alcohol-induced cigarette craving compared to women. Although studies have examined the effects of alcohol consumption on concomitant cigarette smoking or craving, there is a paucity of research examining the reverse pathway (i.e., effects of nicotine on alcohol consumption). Therefore, the second goal is to determine whether nicotine exposure increases alcohol craving and consumption, and to examine gender differences in such responses. Understanding the potential unique biobehavioral mechanisms underlying alcohol and nicotine interactions for men and women may help to tailor early prevention and treatment programs specifically for the sexes.