Amygdala circuits and control of feeding by learned cues

杏仁核回路和通过习得线索控制进食

• 批准号: 6758676
• 负责人: Gorica D Petrovich
• 金额: $ 13.61万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6758676
• 关键词: amygdala; association learning; behavioral /social science research tag; cues; dietary control; experimental brain lesion; hippocampus; immunocytochemistry; in situ hybridization; laboratory rat; motivation; neuroanatomy; neurotoxins; prefrontal lobe /cortex; regulatory gene

DESCRIPTION (provided by applicant): The work under the research plan in this application will extend our understanding of neural systems through which signals from the environment control feeding behavior, while also developing the potential for the applicant, Dr. Gorica Petrovich, to become an independent investigator. The proposed research builds on evidence that food consumption can be modified by learned cues, based on motivational value acquired through association with either rewarding or aversive events. Applying a combination of behavioral and neural systems analysis, Dr. Petrovich proposes to determine the exact brain circuits that allow learning to modulate eating, including the amygdala complex and related forebrain systems. Delineating the brain systems needed for control of food consumption by environmental signals, is a necessary first step toward development of animal models in which factors that control feeding behavior and its associated disorders can be better studied. In these experiments, Dr. Petrovich will extend her technical expertise in neuronal systems and build on a foundation of behavioral theory and empirical studies using a range of learning paradigms. Dr. Gallagher (her sponsor), along with Drs. Peter Holland and Tim Moran will oversee her development under the award, toward the goal of becoming a productive independent scientist and academic faculty member. The mentored career award will also allow the applicant to gain a fuller understanding of the clinical conditions, such as eating disorders; to which her basic research has relevance. The environment at Johns Hopkins University is particularly well suited to the applicant's training with a strong presence in both basic research and clinical areas in the field of neuroscience. All facilities required for the proposed research are available to the applicant, including dedicated office and research space.

描述(申请人提供)：本申请研究计划下的工作将扩大我们对神经系统的理解，通过神经系统，来自环境的信号控制喂养行为，同时也开发了申请人Gorica Petrovich博士成为独立研究员的潜力。这项拟议的研究建立在证据的基础上，即食物消费可以通过学习线索来改变，基于与奖励或厌恶事件相关联而获得的动机价值。彼得罗维奇博士结合了行为和神经系统分析，建议确定学习调节饮食的确切大脑回路，包括杏仁核复合体和相关的前脑系统。通过环境信号描述控制食物消耗所需的大脑系统，是开发动物模型的必要的第一步，在动物模型中，可以更好地研究控制摄食行为及其相关疾病的因素。在这些实验中，彼得罗维奇博士将扩展她在神经系统方面的技术专长，并建立在行为理论和使用一系列学习范式的实证研究的基础上。加拉格尔博士(她的赞助人)将与彼得·霍兰德博士和蒂姆·莫兰博士一起监督她在该奖项下的发展，朝着成为一名富有成效的独立科学家和学术教员的目标迈进。指导职业奖还将使申请者更充分地了解她的基础研究与其相关的临床条件，如饮食失调。约翰霍普金斯大学的环境特别适合申请者的培训，在神经科学领域的基础研究和临床领域都有很强的影响力。申请人可使用拟议研究所需的所有设施，包括专用办公室和研究场所。