Contingent Feeding of Preterms to Reduce Hypoxemia

早产儿的应急喂养以减少低氧血症

基本信息

  • 批准号:
    6700247
  • 负责人:
  • 金额:
    $ 8.72万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2002
  • 资助国家:
    美国
  • 起止时间:
    2002-02-01 至 2006-01-31
  • 项目状态:
    已结题

项目摘要

Preterm infants experience breathing irregularities that lead to significant and frequent episodes of hypoxemia during bottle feeding. Recurrent, transient hypoxemia may contribute to the development of dysfunctional oral-motor feeding patterns, increased expenditure of energy and poor growth, and neurologic injury. The goals of the proposed mentored research are to refine and test the effectiveness of an individualized, contingently-structured feeding intervention for hospitalized preterm infants designed to minimize hypoxemia during bottle feeding. The feeding intervention will begin with an assessment feeding during which the infant's feeding skills and regulatory problems are identified and an individual approach to feeding is designed. Then the infant will be fed once by a standard approach and once by the intervention approach. The intervention approach will consist of strategies that are applied to all infants, for example, preparing the infant to feed, and a contingently-structured component with specific strategies based on the type of feeding difficulties presented by the infant during the feeding. In addition, the efficacy of the addition of supplemental oxygen for the minimization of hypoxemia will be explored with infants who do not respond adequately to the intervention. The intervention will be compared to the standard feeding approach on measures of infant readiness at the outset of the feeding, the number and severity of hypoxemic events during the feeding, and post-feeding measures of feeding tolerance using multivariate repeated measures ANOVA. The investigator's educational aims for the K01 are: (a) to expand knowledge of the respiratory physiology of feeding for preterm infants; (b) to expand knowledge of the development of swallowing in preterm infants and the physiologic bases for supporting effective swallowing and breathing coordination during early preterm infant feeding; (c) to develop competence in the assessment and measurement of swallowing patterns, the identification of swallowing difficulties, and the design of appropriate interventions for swallowing dysregulation; (d) to develop skill in coding behavioral indicators of fatigue during feeding and identifying early behavioral indicators of fatigue, and to develop effective strategies to prevent or respond to fatigue during feeding, (e) to develop skills in designing and implementing longitudinal intervention studies and analyzing longitudinal data, in preparation for submitting an R01 grant proposal on prevention of hypoxemia during preterm infant bottle feeding. The R01 will propose testing the intervention throughout the period of learning to oral feed during hospitalization and examining outcomes of growth, development of feeding skills, and neurodevelopment. If the intervention is effective in improving these outcomes, it will be taught to nurses and parents, who are the primary feeders of preterm infants during hospitalization.
早产儿在奶瓶喂养期间会出现呼吸不规律,导致严重和频繁的低氧血症。反复发作的一过性低氧血症可能导致功能障碍的口腔-运动进食模式、能量消耗增加和生长不良以及神经损伤。建议的指导研究的目标是完善和测试的有效性,个性化的,偶然结构的喂养干预住院早产儿,旨在尽量减少低氧血症奶瓶喂养。喂养干预开始是评估喂养,在此期间确定婴儿的喂养技能和监管问题,并设计个性化的喂养方法。然后,婴儿将通过标准方法喂养一次,通过干预方法喂养一次。干预方法将包括适用于所有婴儿的策略,例如,准备婴儿喂养,以及基于婴儿在喂养过程中出现的喂养困难类型的特定策略的临时结构组成部分。此外,将在对干预反应不充分的婴儿中探索补充供氧对最大限度减少低氧血症的疗效。将干预措施与标准喂养方法在喂养开始时的婴儿准备程度、喂养期间低氧血症事件的数量和严重程度以及使用多变量重复测量ANOVA的喂养耐受性的喂养后测量方面进行比较。研究者对K 01的教育目的是:(a)扩展早产儿喂养的呼吸生理学知识;(B)扩展早产儿吞咽发育的知识以及支持早期早产儿喂养期间有效吞咽和呼吸协调的生理学基础;(c)发展评估和测量吞咽模式、识别吞咽困难和设计吞咽失调的适当干预措施的能力;(d)发展对喂养期间疲劳的行为指标进行编码和识别疲劳的早期行为指标的技能,并发展有效的策略来预防或应对喂养期间的疲劳,(e)发展设计和实施纵向干预研究和分析纵向数据的技能,准备提交一份关于预防早产儿奶瓶喂养期间低氧血症的R 01资助提案。R 01将建议在住院期间学习口服喂养的整个期间测试干预措施,并检查生长、喂养技能发展和神经发育的结果。如果干预措施在改善这些结果方面有效,则将向护士和父母传授,他们是住院期间早产儿的主要喂养者。

项目成果

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SUZANNE M THOYRE其他文献

SUZANNE M THOYRE的其他文献

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{{ truncateString('SUZANNE M THOYRE', 18)}}的其他基金

Symptom Trajectories in Infants and Toddlers at Risk for Chronic Feeding Problems
有慢性喂养问题风险的婴儿和幼儿的症状轨迹
  • 批准号:
    10200149
  • 财政年份:
    2019
  • 资助金额:
    $ 8.72万
  • 项目类别:
Symptom Trajectories in Infants and Toddlers at Risk for Chronic Feeding Problems
有慢性喂养问题风险的婴儿和幼儿的症状轨迹
  • 批准号:
    10412109
  • 财政年份:
    2019
  • 资助金额:
    $ 8.72万
  • 项目类别:
Symptom Trajectories in Infants and Toddlers at Risk for Chronic Feeding Problems
有慢性喂养问题风险的婴儿和幼儿的症状轨迹
  • 批准号:
    10679026
  • 财政年份:
    2019
  • 资助金额:
    $ 8.72万
  • 项目类别:
Symptom Trajectories in Infants and Toddlers at Risk for Chronic Feeding Problems
有慢性喂养问题风险的婴儿和幼儿的症状轨迹
  • 批准号:
    10024081
  • 财政年份:
    2019
  • 资助金额:
    $ 8.72万
  • 项目类别:
Guiding Mothers to Co-Regulate Oral Feeding with Very Preterm Infants
指导母亲与极早产儿共同调节经口喂养
  • 批准号:
    8328603
  • 财政年份:
    2011
  • 资助金额:
    $ 8.72万
  • 项目类别:
Guiding Mothers to Co-Regulate Oral Feeding with Very Preterm Infants
指导母亲与极早产儿共同调节经口喂养
  • 批准号:
    8189524
  • 财政年份:
    2011
  • 资助金额:
    $ 8.72万
  • 项目类别:
Contingent Feeding of Preterms to Reduce Hypoxemia
早产儿的应急喂养以减少低氧血症
  • 批准号:
    6434327
  • 财政年份:
    2002
  • 资助金额:
    $ 8.72万
  • 项目类别:
Contingent Feeding of Preterms to Reduce Hypoxemia
早产儿的应急喂养以减少低氧血症
  • 批准号:
    6621437
  • 财政年份:
    2002
  • 资助金额:
    $ 8.72万
  • 项目类别:
COREGULATION OF VERY LOW BIRTHWEIGHT FEEDING
极低出生体重喂养的共同监管
  • 批准号:
    2258981
  • 财政年份:
    1995
  • 资助金额:
    $ 8.72万
  • 项目类别:
COREGULATION OF VERY LOW BIRTHWEIGHT FEEDING
极低出生体重喂养的共同监管
  • 批准号:
    2258980
  • 财政年份:
    1995
  • 资助金额:
    $ 8.72万
  • 项目类别:
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