开发一种新型酒精依赖剂-猫眼课题宝

开发一种新型酒精依赖剂

批准号：

6703325

负责人：

John V. Schloss

金额：

$11.5万

依托单位：

THIOPHARMA, INC.

依托单位国家：

美国

项目类别：

财政年份：

2003

资助国家：

美国

项目状态：

已结题

起止时间：

2003-09-25 至 2004-03-31

来源：

https://reporter.nih.gov/project-details/6703325

关键词：

alcoholism /alcohol abuse alcoholism /alcohol abuse chemotherapy analytical method disulfiram drug addiction drug design /synthesis /production electrospray ionization mass spectrometry laboratory rat matrix assisted laser desorption ionization method development pharmacokinetics sulfoxide thiocarbamate toxicology

中文摘要

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英文摘要

DESCRIPTION (provided by applicant): Studies are proposed to complete the development of S-methyl N, Ndiethylthiolcarbamate sulfoxide (DETC-MeSO), a novel agents for the treatment of alcohol dependence. Specifically the following studies will be performed. 1. Complete the process chemistry development for DETC-MeSO and its Isomers. (carried out at Thiopharma, Inc) 2. Synthesize sufficient scale UP quantities for preclinical toxicology studies. (carried out at Pharm-Eco Laboratories, Inc) 3. Carry out pharmacokinetic studies in rats to support preclinical toxicology studies. (carried out at The University of Kansas) 4. Preclinical toxicology studies in rats and dogs. (carried out at Battelle).

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