CORE CENTER

描述（由申请人提供）：男孩镇国家研究医院 （BTNRH）核心中心的设计是为了满足当前和预期的需求， 三个领域：1）实验室计算，2）使用转基因和基因敲除小鼠 模型，以及3）招募人类受试者。 第一个拟议的研究核心，实验室计算，根据 斯蒂芬·尼利的方向，将提供中央支持的独特需求 与实时数据收集以及研究数据库支持相关。 通过在R01之间共享工程和编程人员， 通过提供开发更一般数据所需的额外支持， 收集和分析工具，这一核心将促进软件共享 在我们的实验室和听觉研究中， 整个社区。 第二个研究核心，转基因小鼠模型，在 多米尼克·科斯格罗夫将为使用独特的小鼠品系提供支持， 通过提供综合畜牧业和基因分型服务进行研究。的 在我们的动物护理设施中增加一名技术人员将使我们能够采用 统一的高标准护理，实施常规健康监测， 进行更有效的育种计划。增加一名技术人员 基因分型负责人将提供育种所需的信息 及时进行研究。这一核心将通过以下方式促进合作： 促进研究计划内小鼠品系的共享。 第三个研究核心，人类受试者招募，在 迈克尔·戈尔加，将提供更好的访问特定类型的研究课题 同时保持机密性。受试者招募是一大瓶颈 我们所有的研究项目。通过协调一致的努力，我们不仅可以 在项目中实现效率的大幅提高，而且还可以使 跨研究项目的合作，将扩大范围的 研究计划。 我们目前的用户群包括10个R01赠款和5个P01项目， 高级工作人员担任主要调查员或共同调查员。的 关键人员名单包括另外4名可能加入的工作人员 核心中心五年周期内的用户群。

DESCRIPTION (provided by applicant): The Boys Town National Research Hospital (BTNRH) Core Center has been designed to meet current and anticipated needs in three areas: 1) laboratory computing, 2) use of transgenic and knockout mouse models, and 3) recruitment of human subjects. The first of the proposed research cores, Laboratory Computing, under the direction of Stephen Neely, will provide central support for the unique needs associated with real-time data collection as well as research database support. By making it feasible to share engineering and programming staff across R01s and by providing the additional support required to develop more general data collection and analysis tools, this core will facilitate sharing of software across laboratories both within our facility and with the auditory research community as a whole. The second research core, Transgenic Mouse Models, under the direction of Dominic Cosgrove, will provide support for the use of unique mouse strains in research by providing integrated animal husbandry and genotyping services. The addition of a technician to our Animal Care Facility will allow us to adopt a uniformly high standard of care, implement routine health monitoring, and operate a more effective breeding program. The addition of a technician responsible for genotyping will provide the information required for breeding and research in a timely manner. This core will foster collaboration by facilitating the sharing of mouse strains within the research program. The third research core, Human Subject Recruitment, under the direction of Michael Gorga, will provide better access to specific types of research subjects while maintaining confidentiality. Recruitment of subjects is a major bottleneck in all of our research projects. With a coordinated effort, we not only can achieve a great increase in efficiency within projects, but also can enable collaboration across research projects that will extend the range of the research program. Our current user base includes 10 R01 grants and 5 P01 projects for which 16 senior staff members serve as principal investigators or co-investigators. The list of key personnel includes 4 additional staff members who are likely to join the user base during the five-year cycle of the Core Center.