The development of a cost-effective and stable single-administration vaccine (SAV) formulation to achieve vaccination regimen reduction

制药业的发展和世卫组织发起的儿童疫苗行动导致了单次给药疫苗概念的产生和发展。sav是一种控释制剂，目的是在一次注射中提供起始剂量和加强剂量。尽管在过去四十年中不断努力，但市场上还没有单一施用的疫苗配方。为了降低配方成本并实现可扩展性，将使用三喷嘴喷雾干燥机。这种技术可以提供双重封装，在一个步骤中解决两大挑战（抗原稳定性和释放机制）。其目的是创建一个新的平台，可以装载抗原，能够产生优于传统疫苗的免疫原性。

Both the evolution of the pharmaceutical industry and the Children's Vaccine Initiative launched by WHO led to the genesis and development of the idea of single administration vaccines (SAVs). SAVs are controlled release formulations aiming to provide prime and booster doses in a single shot. Despite continuing efforts during the last forty years, there is no single administration vaccine formulation on the market yet. To reduce the formulation cost and enable scalability, a three fluid-nozzle spray dryer will be used. Such techniques can provide double encapsulation to address the two major challenges (antigen stability, release mechanism) in a single step. The aim is to create a novel platform that can be loaded with antigens capable of generating non-inferior immunogenicity to conventional vaccines.