Investigating the role of SARM1 in Wallerian Degeneration

研究 SARM1 在华勒变性中的作用

• 批准号: 2432291
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2432291
• 关键词: Investigating; role; SARM1; Wallerian; Degeneration

Wallerian degeneration was discovered in axon injury, but has been shown to be involved in many neurodegenerativediseases. When active, the NADase SARM1 is a key executioner of the Wallerian degeneration (WD) pathway inneurons. The Coleman group has characterised several activators of SARM1 that differ in potency. This research projectwill study the molecular basis of these differences using both cell-free systems and neuronal culture, as part of a longertermaim to block activation and preserve axons in disease.

Wallerian变性是在轴突损伤中发现的，但已被证明与许多神经退行性疾病有关。当激活时，NADase SARM 1是神经元中沃勒变性（WD）通路的关键执行者。科尔曼小组已经鉴定了几种效力不同的SARM 1激活剂。本研究项目使用无细胞系统和神经元培养来研究这些差异的分子基础，作为阻断激活和保护疾病中轴突的长期方法的一部分。