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Nano Silver-Hydroxyapatite Coatings - biocompatibility with oral cells to improve abutment integrity for periodontal health.

纳米银羟基磷灰石涂层 - 与口腔细胞的生物相容性，可改善基台完整性，促进牙周健康。

基本信息

批准号：
2432313
负责人：
金额：
--
依托单位：
Plymouth University
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2020
资助国家：
英国
起止时间：
2020 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2432313
关键词：
Nano Silver Hydroxyapatite Coatings biocompatibility

项目摘要

This project is an exciting opportunity to develop novel silver-hydroxyapatite nanocoatings to reduce failure of dental implants. The interdisciplinary project combines nanotechnology with leading biomedical science expertise, in a real-world clinical setting to investigate the biocompatibility of antibacterial nanocoatings with oral cells to improve abutment integrity for periodontal health. Despite the high success rates of dental implants, 5-10% of them are still reported to fail and must be removed. One of the most common causes of implant failure is peri-implantitis, which is caused by bacterial biofilm formation on the implant surfaces. Modification of the surface nanotopography has been identified as one of the strategies to control bacterial adherence to implants and improve clinical outcomes. Silver nanoparticles are known for their antibacterial properties, whereas hydroxyapatite is a chemical similar to the mineral component of natural bone and teeth. Our team has demonstrated that silver-hydroxyapatite hybrid nanocoatings applied to the surface of medical implants are antibacterial but also biocompatible with human osteoblasts, suggesting good fusion of the implants to the jaw bone is achieved. However, shrinkage of the gingiva at the abutment margins, with subsequent infection and micro-leakage in the sub-gingival crevice can lead to implant failure, as well as other oral health problems.

该项目是开发新型银羟基磷灰石纳米涂层以减少种植体失败的一个令人兴奋的机会。该跨学科项目将纳米技术与领先的生物医学科学专业知识相结合，在现实世界的临床环境中研究抗菌纳米涂层与口腔细胞的生物相容性，以改善牙周健康的基牙完整性。尽管种植牙成功率很高，但据报道仍有5-10%的种植牙失败，必须移除。种植体失败最常见的原因之一是种植体周围炎，这是由种植体表面形成细菌生物膜引起的。表面纳米形貌的修饰已被确定为控制细菌粘附植入物和改善临床结果的策略之一。银纳米颗粒以其抗菌特性而闻名，而羟基磷灰石是一种类似于天然骨骼和牙齿的矿物成分的化学物质。我们的团队已经证明，应用于医用植入物表面的银羟基磷灰石混合纳米涂层不仅抗菌，而且与人类成骨细胞具有生物相容性，这表明植入物与颌骨实现了良好的融合。然而，基牙边缘的牙龈萎缩，随之而来的感染和龈下缝隙的微渗漏会导致种植体失败，以及其他口腔健康问题。