PEDIATRIC CLINICAL RESEARCH PHARMACOLOGY FELLOWSHIP

儿科临床研究药理学奖学金

• 批准号: 6636775
• 负责人: Brookie Manning Best
• 金额: $ 4.81万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6636775
• 关键词: adolescence (12-20); child (0-11); clinical research; drug interactions; human population study; human subject; pediatrics; pharmacokinetics; pharmacology; postdoctoral investigator

DESCRIPTION (the applicant?s description verbatim): The primary goal of this fellowship is to produce an independent clinical pharmacologist who can effectively pursue a career in clinical pharmacology research with a pediatric emphasis. This fellowship will provide the coursework, training, and research experience necessary to become a clinical research pharmacologist certified by the American Board of Clinical Pharmacology (ABCP). Didactic courses will include Applied Epidemiology, Applied Biostatistics, Design of Clinical Trials, Scientific Ethics, Investigational and Marketing Applications for Drugs, Biologics and Medical Devises, S-PLUS Fundamentals, and Population Pharmacokinetics-NONMEM (non-linear mixed-effects modeling). Proficiency in the software programs SAS, S-PLUS, WinNonLin, TDMS, Innaphase, Adapt II, WinNonMix, NONMEM, RIDO and Pharsight will be achieved. Several research projects will be completed during the fellowship that will provide training in the following areas: 1) standard pharmacokinetic/pharmacodynamic studies in pediatric and adult patients; 2) pharmacokinetic drug interaction studies; 3) population pharmacokinetic/ pharmacodynamic studies in children and adults; 4) trial simulation techniques; and 5) design and coordination of pediatric clinical pharmacology trial.

申请人（The applicant？的描述逐字）：这一主要目标 奖学金的目的是培养一名独立的临床药理学家， 有效地追求事业在临床药理学研究与儿科 着重该奖学金将提供课程，培训和研究 成为临床研究药理学家所需的经验， 美国临床药理学委员会（ABCP）教学课程将 包括应用流行病学，应用生物统计学，临床试验设计， 科学道德，药物的研究和上市申请， 生物制品和医疗器械、S-PLUS基础知识和人群 药代动力学-NONMEM（非线性混合效应建模）。熟练 软件程序SAS、S-PLUS、WinNonLin、TDMS、Innapase、Adapt II、WinNonMix NONMEM、RIDO和Pharsight将实现。一些研究项目将 在研究金期间完成，将提供以下培训 领域：1）儿科标准药代动力学/药效学研究 成人患者; 2）药代动力学药物相互作用研究; 3）人群 儿童和成人的药代动力学/药效学研究; 4）试验 模拟技术; 5）儿科临床的设计和协调 药理学试验