CENTER FOR METABOLIC RESEARCH ON HIV AND DRUG USE

该中心的目的是为研究不同种族（白种人、西班牙裔和非裔美国人）使用各种非法药物的慢性吸毒者的营养、内分泌和代谢方面的艾滋病毒感染提供科学资源。艾滋病毒阳性吸毒者面临着一系列独特的问题和挑战，这些问题和挑战可能使他们的病情恶化，包括营养不良、医疗保健不足、难以坚持复杂的治疗方案，以及使用已知会损害代谢功能的特定药物。然而，对一般HIV阳性人群中HIV感染的总体营养、内分泌和代谢影响的调查很少扩展到吸毒人群，这一群体中有50%的新HIV感染发生。该中心将由6个核心组成：行政，发展，吸毒者

The aim of this Center is to provide scientific resources for studying the nutritional, endocrine, and metabolic aspects of HIV infection in chronic drug users of different ethnicities (Caucasian, Hispanic, and African-Americans) who are using various types of illicit drugs. HIV-positive drug users face a unique set of issues and challenges that may exacerbate their illness, including poor nutrition, inadequate medical care, difficulties adhering to complicated therapeutic regimens, and the use of specific drugs known to impair metabolic function. Investigation of the overall nutrition, endocrine, and metabolic effects of HIV infection in the general HIV-positive population, however, seldom extends to the drug using population, a group in which 50% of new HIV infections occurs. This Center will consist of 6 Cores: Administrative, Developmental, Drug User Resources, Nutrition and Metabolism, Endocrine, and Epidemiology/Biostatistics. The Center will build upon an existing infrastructure of studies in drug users at four East Coast institutions (Tufts University School of Medicine in Boston, Massachusetts; Brown University School of Medicine in Providence, Rhode Island; Johns Hopkins Medical Institutions in Baltimore, Maryland; and the New York Academy of Medicine, in New York City, New York). Tufts has developed programs in specific nutrition and metabolic aspects of HIV infection and has a research program in Hispanic drug users with and without HIV. Brown University has developed expertise in conducting research among specialized populations, including injection drug users, substance abusing women, and incarcerated drug users. Johns Hopkins has research in endocrine disorders among drug users with HIV, and has active longitudinal studies of African-American injection drug users. The New York Academy of Medicine's Center for Urban Epidemiologic Studies has several ongoing research studies related to HIV infection in drug using populations. The proposed Center will combine the complementary resources and expertise that exist at each of the collaborating sites to develop a new research program that will focus on the nutritional, metabolic, and endocrine abnormalities in HIV-positive and HIV-negative drug users.