CORE GRANT FOR VISION RESEARCH

田纳西大学孟菲斯分校在过去两年中建立了视觉研究中心和眼科研究所，为支持视觉研究提供了主要资源。扩大的支持部分反映在眼科的发展上，在过去四年中，眼科获得了几位基础和临床科学家。这一扩展补充了解剖学和神经生物学以及生理学部门内强大的视觉研究小组，以及两个相邻机构的研究人员。裘德儿童研究医院和南方视光学院。目前，有超过20名活跃的视觉科学家与资助的研究项目参与视觉研究中心。为了加强正在进行的nei支持的项目，将支持四个核心模块，每个模块都服务于我们小组研究的积极方面。成像模块包含一个用于光学显微镜的高分辨率数字图像分析系统，一个快速响应的钙成像系统，一个倒置荧光显微显微镜和一个最先进的机动低温恒温器。分子生物学模块提供自动DNA测序和基因分型，定量实时PCR和基因阵列芯片扫描技术。细胞生物学模块为获取、储存和培养人类供体组织和人类细胞系提供了一个中心设施，用于形态学、生化和遗传分析。生物信息学模块协助基于计算机的数据库管理，生物统计分析，大型数据集的互联网出版，图像分析和基因组学的高级软件支持，以及基础研究设计和解释。模块被安置在新成立的眼科研究所和神经科学研究所，允许方便地访问所有的研究小组。已承诺为这一努力提供强有力的机构支持，包括总额为25万美元的设备、技术支持和仪器服务合同。

Having established the Center for Vision Research and The Ophthalmology Institute within the past two years, The University of Tennessee, Memphis, is providing major resources to support vision research. Part of the expanded support is reflected in the growth of the Department of Ophthalmology which has gained several basic and clinical scientist over the past four years. This expansion complements a strong vision research group within the Departments of Anatomy and Neurobiology, and Physiology, as well as investigators at two neighboring institutions-St. Jude Children's Research Hospital and Southern College of Optometry. At present, over 20 active vision scientists with funded research programs participate in the Center for Vision Research. To enhance ongoing NEI-supported programs, four core modules that each serve active facets of our group's research will be supported. The Imaging Module contains a high-resolution digital image analysis system for light microscopy, a rapid-response calcium imaging system, an inverted fluorescence photomicroscope, and a state-of the-art motorized cryostat. The Molecular Biology Module provides automated DNA sequencing and genotyping, quantitative real-time PCR, and gene array chip scanning technology. The Cell Biology Module provides a central facility for acquiring, storing, and culturing human donor tissues and human cell lines for morphologica1, biochemical, and genetic analysis. The Bioinformatics Module assists in computer-based database management, biostatistical analyses, Internet publication of large datasets, high level software support for image analysis and genomics, and basic research design and interpretation. Modules are housed within the newly established Ophthalmology Institute and in the Neuroscience Institute, allowing easy access to all research groups. Strong institutional support has been pledged for this effort and includes a total outlaw of $250,000 for equipment, technical support, and instrument service contract.