Plasma Markers of Dietary Intervention to Delay Cogniti

延迟认知饮食干预的血浆标志物

• 批准号: 6780277
• 负责人: JAE H KANG
• 金额: $ 7.79万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-15 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6780277
• 关键词: antioxidants; behavior test; biomarker; carotene; carotenoids; clinical research; cognition; diet therapy; female; folate; homocysteine; human subject; longitudinal human study; memory; neuroprotectants; nurses; nutrition of aging; nutrition related tag; nutritional epidemiology; questionnaires; tocopherols; vitamin B12; vitamin B6

We propose to conduct a pilot study of dietary interventions to delay cognitive decline in older women. Since biomarkers may better reflect nutrients bioavailable to tissues than dietary questionnaires, we propose to prospectively examine plasma markers of a wide array of antioxidants (alpha-carotene, beta-carotene, lutein/zeaxanthin, lycopene, beta-cryptoxanthin, alpha-tocopherol and gamma-tocopherol) and homocysteine, folate and vitamins B6 and B12 and their association with cognitive decline among older participants of the Nurses Health Study (NHS). The NHS began in 1976 among 121,700 women aged 30 to 55; in 1989-1990, over 32,000 blood samples were collected. From 1995-2001, approximately 19,000+ women free of stroke and aged 70 or above completed a baseline telephone cognitive interview consisting of a variety of tests measuring general cognitive ability, episodic memory, category fluency and attention. A second wave of our cognitive tests has been administered and the third assessments are ongoing, thus allowing us to prospectively measure change in cognitive function from baseline. Several lines of evidence establish that a single plasma measure of the proposed markers well-represent long-term status and accumulating evidence indicates that earlier life exposures may be particularly important for neuroprotection in older ages. We will utilize controls from previous nested case-controls from the NHS of breast and colon cancer, colon polyps, lens opacities and heart disease for whom measurements of plasma antioxidants, homocysteine and B vitamins and cognitive function have already been completed (n=567 for homocysteine/B vitamins and 724 for plasma antioxidants). We will be able to examine both the baseline performance and longitudinal change in cognitive function on each test over time in relation to various plasma level groups, using generalized estimating equations of repeated measures with random effects.The Principal Investigator is a new, young researcher, and the proposed grant will be important in facilitating her career in aging research. Importantly, results from the proposed grant will lay the groundwork for a future, large-scale comprehensive study to examine dietary interventions to delay cognitive function.

我们建议开展一项饮食干预试点研究，以延缓老年女性认知能力下降。由于生物标志物可能比饮食问卷更好地反映组织生物可利用的营养物质，因此我们建议前瞻性地检查多种抗氧化剂（α-胡萝卜素、β-胡萝卜素、叶黄素/玉米黄质、番茄红素、β-隐黄质、α-生育酚和γ-生育酚）和同型半胱氨酸的血浆标志物， 叶酸、维生素 B6 和 B12 及其与护士健康研究 (NHS) 老年参与者认知能力下降的关系。 NHS 始于 1976 年，覆盖 121,700 名 30 至 55 岁的女性； 1989年至1990年期间， 收集了 32,000 份血液样本。从 1995 年到 2001 年，大约 19,000 多名没有中风且年龄在 70 岁或以上的女性完成了基线电话认知访谈，其中包括测量一般认知能力、情景记忆、类别流畅性和注意力的各种测试。我们已经进行了第二波认知测试，第三次评估正在进行中，从而使我们能够前瞻性地衡量认知功能相对于基线的变化。几条证据表明，所提出的标记物的单一血浆测量值很好地代表了长期状态，并且积累的证据表明 早年的暴露对于老年人的神经保护可能特别重要。我们将利用之前 NHS 乳腺癌和结肠癌嵌套病例对照的对照， 结肠息肉、晶状体混浊和心脏病患者的血浆抗氧化剂、同型半胱氨酸和 B 族维生素以及认知功能的测量已经完成（同型半胱氨酸/B 族维生素 n=567，血浆抗氧化剂 n​​=724）。我们将能够使用具有随机效应的重复测量的广义估计方程，检查每次测试的基线表现和认知功能随时间的纵向变化与不同血浆水平组的关系。首席研究员是一位新的年轻研究人员，拟议的资助对于促进她在衰老研究领域的职业生涯非常重要。重要的是，拟议拨款的结果将为未来的大规模综合研究奠定基础，以检查饮食干预措施是否延缓认知功能。