Language Systems in Schizophrenia: Behavioral & ERP Data

描述：（由申请人提供）这项为期五年的研究的主要目的是 来加深我们对精神分裂症谱系中语言功能障碍的理解 使用事件相关电位的疾病，事件相关伽马，实验性 神经心理学和临床测量在三个DSM-IV诊断的临床 组：慢性精神分裂症（CS）、首发精神分裂症（FES）和 典型人格障碍（SPD）及其配对的正常对照。的 使用这三个临床组将提供研究差异和 精神分裂症谱系中语言障碍的相似性。 中国男性和女性语言加工的异同 这三个临床组将作为次要目标进行研究。 为了得出一个全面的语言功能障碍模型， 精神分裂症谱系，我们将使用语言的启发式模型， 语义组织包括三个不同但相互作用的组成部分 称为语义网络的属性、过程和内容。 属性指的是单词之间的连接权重，以及单词的大小和 网络的连贯性。过程指的是激活、抑制和情境 使用（本地和全局）。网络内容包括文字、数字和 符号将不会被测量。我们建议在语言上逐步细分 功能障碍以CS>FES>SPD为主。 我们将对三名精神分裂症患者进行为期五年的研究， 频谱组：1）30例CS患者; 2）30例FES患者; 3）30例 30例SPD患者和30例正常对照组 （n=90）。每个对照组将在年龄、性别和父母SES方面进行匹配， 其各自的临床组和所有受试者将是右利手， 英语为主要语言。 我们将使用ERP，事件相关伽马，实验神经心理学， 临床数据（思维障碍指数TDI），研究语言障碍， 三个临床组。因此，我们预测语义网络中的过度激活， 由N400索引，短刺激起始时间（SOA）的词对研究 在SPD，FES和CS中。异常抑制/上下文利用的证据 在N400、句子和段落研究中可以找到这些过程，其中大多数 CS>FES>SPD严重受损。异常性质的证据 语义网络将在单词回忆的神经心理学研究中被发现， 在N400、词对、短SOA研究中，以及在事件相关伽马数据中， 它是FES和CS，但不是SPD。四个数据集之间的相关性分析 将试图描述四个领域之间的关系， 我们预测，女性在所有方面的损伤都会比男性少。 这些措施。

DESCRIPTION: (provided by applicant) The broad aim of this five year study is to advance our understanding of language dysfunction in schizophrenia spectrum disorder using event-related potential, event-related gamma, experimental neuropsychological and clinical measures in three DSM-IV diagnosed clinical groups: chronic schizophrenia (CS), first episode schizophrenia (FES) and schizotypal personality disorder (SPD), and their matched normal controls. The use of the three clinical groups will afford studying both differences and similarities in language impairment across the schizophrenia spectrum. Similarities and differences in language processing in males and females in these three clinical groups will be studied as a secondary goal. In order to arrive at a comprehensive model of language dysfunction in the schizophrenia spectrum, we will use a heuristic model of language in which semantic organization includes three distinct but interacting components referred to as properties, processes, and content of semantic networks. Properties refer to connectivity weights among words, and to the size and the coherence of networks. Processes refer to activation, inhibition, and context use (both local and global). Network contents including words, numbers, and symbols will not be measured. We propose a gradual breakdown in language function with most impairment in CS>FES>SPD. We will test these hypotheses in a five-year study of three schizophrenia spectrum groups: 1) 30 patients with CS; 2) 30 patients with FES; and 3) 30 individuals with SPD, and 30 normal controls matched to each clinical group (n=90). Each control group will be matched for age, gender and parental SES to its respective clinical group and all subjects will be right handed, with English as their primary language. We will use ERP, event-related gamma, experimental neuropsychological, and clinicaldata (Thought Disorder Index TDI), to study language disorder in the three clinical groups. We thus predict over-activation in semantic networks as indexed by the N400, word-pair study at short stimulus onset asynchrony (SOA) in SPD, FES, and CS. The evidence of abnorma inhibitory/context utilization processes will be found in the N400, sentence and paragraph studies, with most severe impairment in CS>FES>SPD. The evidence of abnormal properties in semantic networks will be found in the neuropsychological study of word recall, in the N400, word-pair, short SOA study, and in the event-related gamma data, it FES and CS, but not in SPD. Correlational analyses among the four data sets will seek to characterize the relationships among the four domains of analysis.We predict that females will show less impairment than males on all these measures.