Design of targeted intravesical therapies for treating recurrent urinary tract infections

治疗复发性尿路感染的靶向膀胱内治疗的设计

• 批准号: 2437927
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2437927
• 关键词: Design; targeted; intravesical; therapies; treating

The National Institute for Health Research in 2016 reported that UTIs are among the most common types of infections within excess of 92 million people affected worldwide. UTIs are a significant cause of mortality, especially amongst the elderly population, with UTI related symptoms accounting for between 1-3% of all primary care consultations and being the main reason for 13.7% of community antibiotic prescriptions. The treatment costs of UTIs place a significant burden on the NHS. The current antibiotic treatments are mostly systemic in nature which exposes the whole body to the drug. This has contributed to the recently reported 6% of drug-resistance in UTI cases. This project will aim to develop and evaluate a new nanoparticle-based localised treatment that can directly administer into the bladder, the target organ.

2016年，国家卫生研究所报告称，尿路感染是全球9200多万受影响人口中最常见的感染类型之一。尿路感染是导致死亡的重要原因，特别是在老年人群中，与尿路感染相关的症状占所有初级保健咨询的1-3%，是社区开出13.7%的抗生素处方的主要原因。尿路感染的治疗费用给NHS带来了巨大的负担。目前的抗生素治疗大多是全身性的，这会使整个身体暴露在药物之下。这导致了最近报道的尿路感染病例中6%的耐药性。该项目的目标是开发和评估一种新的基于纳米颗粒的局部治疗方法，这种治疗方法可以直接进入目标器官膀胱。