Evolution of adaptive immunity to gluten in coeliac disease.

乳糜泻中麸质适应性免疫的进化。

• 批准号: nhmrc : 1032205
• 负责人: Dr Jason Tye-Din
• 金额: $ 31.48万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/evolution-adaptive-immunity-coeliac-disease/110843
• 关键词: Evolution; adaptive; immunity; gluten; coeliac

Coeliac disease affects 1 in 100 Australians and can cause significant health problems. Under-diagnosis and a difficult, costly treatment (lifelong gluten free diet) are serious clinical issues. The feasibility of simpler diagnostics and therapies in children and adults for coeliac disease depends on whether children and adults react in the same way to gluten. This proposal seeks to determine whether the immune response to gluten changes over time and establish the feasibility of peptide-based applications.

腹腔疾病影响每100名澳大利亚人中的1人，并可能导致严重的健康问题。诊断不足和困难，昂贵的治疗（终身无麸质饮食）是严重的临床问题。儿童和成人腹腔疾病的简单诊断和治疗的可行性取决于儿童和成人对麸质的反应是否相同。该提案旨在确定对麸质的免疫反应是否随时间而变化，并建立基于肽的应用的可行性。