Evolution of adaptive immunity to gluten in coeliac disease.

每100个澳大利亚人中就有1人患有乳糜泻，并可能导致严重的健康问题。诊断不足和困难、昂贵的治疗（终生无麸质饮食）是严重的临床问题。对儿童和成人进行更简单的乳糜泻诊断和治疗的可行性取决于儿童和成人对谷蛋白的反应是否相同。本研究旨在确定对谷蛋白的免疫反应是否会随着时间的推移而改变，并建立基于肽的应用的可行性。

Coeliac disease affects 1 in 100 Australians and can cause significant health problems. Under-diagnosis and a difficult, costly treatment (lifelong gluten free diet) are serious clinical issues. The feasibility of simpler diagnostics and therapies in children and adults for coeliac disease depends on whether children and adults react in the same way to gluten. This proposal seeks to determine whether the immune response to gluten changes over time and establish the feasibility of peptide-based applications.