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Evolution of pertussis epidemics and effect of genotypes on infection outcomes and immunisation

Evolution of pertussis epidemics and effect of genotypes on infection outcomes and immunisation
百日咳流行病的演变以及基因型对感染结果和免疫接种的影响
批准号：
nhmrc : 1011942
负责人：
A/Pr Nicholas Wood
金额：
$43.86万
依托单位：
The University of New South Wales
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2011
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2011-01-01 至 2014-12-31
来源：
https://researchdata.edu.au/evolution-pertussis-epidemics-outcomes-immunisation/109622
关键词：
Evolutionpertussisepidemicseffectgenotypes

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中文摘要
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英文摘要
Pertussis, or whooping cough, is caused by Bordetella pertussis. Despite high vaccine coverage, the incidence of pertussis has increased substantially in recent years in Australia. One of the contributing factors is changes in the pertussis strains. This project will determine the genetic composition and virulence characteristics of epidemic strains in Australia and investigate the effect of these strains on disease severity and vulnerability of vaccinated individuals to infection.
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