Improved DBM ROC Methods for Diagnostic Radiology
改进的诊断放射学 DBM ROC 方法
基本信息
- 批准号:6729883
- 负责人:
- 金额:$ 43.58万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-04-01 至 2007-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant):
This proposal addresses a fundamental methodological problem in diagnostic radiology research: how to evaluate the diagnostic performance of imaging modalities. Receiver operating characteristic (ROC) analysis is an accepted procedure for measuring how well imaging modalities allow physicians to detect disease. Traditional statistical comparison of different imaging modalities only analyzes ROC measures of a single radiologist from each modality. Dorfman, Berbaum and Metz (1992) developed a statistical methodology that overcomes this limitation and provides a comprehensive framework within which to analyze ROC studies with multiple readers, taking into account both reader-sample and case-sample variation. The Dorfman-Berbaum-Metz (DBM) methodology allows greater statistical power to detect clinically meaningful differences in diagnostic performance than single-radiologist approaches. Its validity has been tested extensively using computer simulations and has wide acceptance in diagnostic radiology experiments. Because DBM methodology relies on ROC analysis for its dependent measures, the robustness and accuracy of the ROC analysis affect the statistical precision and power of DBM methodology. DBM analysis of some experiments fails because of flaws in traditional ROC measures. Since the DBM methodology was developed, there have been fundamental advances in ROC analysis, which provide more interpretable measures. DBM could be more robust and statistically powerful if it took advantage of these advances. To accomplish this we propose building an integrated, public-domain software resource to bring together methodological advantages previously only available in separate programs. The specific aims are: (1) develop a new modular DBM software architecture that is freely accessible by other software and allows greater flexibility in ROC analysis; (2) develop "proper" ROC analysis modules that provide more interpretable ROC results and study the resulting DBM statistical power; (3) develop modules for types of ROC analysis that take into account location of reported disease and multiple reports of disease, features that have been shown to improve statistical power; (4) develop modules and procedures to merge DBM methodology with standard statistical software to answer more complex experimental questions; and (5) use DBM re-analysis of published data to provide estimates of minimum reader and case sample size combinations needed to detect various performance differences with power for various imaging areas. Completing these aims will enhance the effectiveness of the primary method used to assess the diagnostic performance of new imaging systems. This will lead to better radiology research, which will raise the quality and lower the cost of health care.
描述(由申请人提供):
该建议解决了诊断放射学研究中的一个基本方法学问题:如何评价成像模式的诊断性能。受试者工作特征(ROC)分析是一种公认的程序,用于测量成像模式如何使医生能够检测疾病。传统的不同成像模式的统计比较仅分析来自每种模式的单个放射科医生的ROC测量。Dorfman、Berbaum和梅斯(1992)开发了一种统计方法,克服了这一局限性,并提供了一个综合框架,在此框架内分析多个读者的ROC研究,同时考虑读者样本和病例样本的变化。Dorfman-Berbaum-梅斯(DBM)方法比单一放射科医师方法具有更大的统计功效,可以检测出诊断性能中有临床意义的差异。它的有效性已被广泛使用计算机模拟测试,并在诊断放射学实验中得到广泛接受。由于DBM方法依赖于ROC分析,因此ROC分析的稳健性和准确性影响DBM方法的统计精度和功效。DBM分析的一些实验失败,因为在传统的ROC措施的缺陷。自从DBM方法被开发以来,ROC分析有了根本性的进步,提供了更多可解释的措施。如果DBM利用这些进步,它可能会更强大,统计功能也更强大。为了实现这一目标,我们建议建立一个集成的,公共领域的软件资源,汇集方法的优势,以前只在单独的程序。具体目标是:(1)开发一种新的模块化DBM软件架构,该架构可由其他软件免费访问,并允许ROC分析具有更大的灵活性;(2)开发“适当的”ROC分析模块,以提供更可解释的ROC结果,并研究由此产生的DBM统计功效;(3)开发用于ROC分析类型的模块,其考虑到所报告的疾病的位置和疾病的多个报告,(4)开发模块和程序,将DBM方法与标准统计软件合并,以回答更复杂的实验问题;(5)利用DBM技术,分析已发表的数据,以提供检测各种性能差异所需的最小阅片人和病例样本量组合的估计值,以及各种成像领域。完成这些目标将提高用于评估新成像系统诊断性能的主要方法的有效性。这将导致更好的放射学研究,这将提高医疗保健的质量和降低成本。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kevin Staley Berbaum其他文献
Kevin Staley Berbaum的其他文献
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{{ truncateString('Kevin Staley Berbaum', 18)}}的其他基金
Improved DBM ROC Methods for Diagnostic Radiology
改进的诊断放射学 DBM ROC 方法
- 批准号:
6844348 - 财政年份:2003
- 资助金额:
$ 43.58万 - 项目类别:
Improved DBM ROC Methods for Diagnostic Radiology
改进的诊断放射学 DBM ROC 方法
- 批准号:
7598948 - 财政年份:2003
- 资助金额:
$ 43.58万 - 项目类别:
Improved DBM ROC Methods for Diagnostic Radiology
改进的诊断放射学 DBM ROC 方法
- 批准号:
6601919 - 财政年份:2003
- 资助金额:
$ 43.58万 - 项目类别:
Improved DBM ROC Methods for Diagnostic Radiology
改进的诊断放射学 DBM ROC 方法
- 批准号:
7799273 - 财政年份:2003
- 资助金额:
$ 43.58万 - 项目类别:
Improved DBM ROC Methods for Diagnostic Radiology
改进的诊断放射学 DBM ROC 方法
- 批准号:
7503120 - 财政年份:2003
- 资助金额:
$ 43.58万 - 项目类别:
Improved DBM ROC Methods for Diagnostic Radiology
改进的诊断放射学 DBM ROC 方法
- 批准号:
7259943 - 财政年份:2003
- 资助金额:
$ 43.58万 - 项目类别:
Improved DBM ROC Methods for Diagnostic Radiology
改进的诊断放射学 DBM ROC 方法
- 批准号:
7008561 - 财政年份:2003
- 资助金额:
$ 43.58万 - 项目类别: