The Effect of Hypertonic Resuscitation for Blunt Trauma
The Effect of Hypertonic Resuscitation for Blunt Trauma
批准号:
6746971
负责人:
EILEEN M BULGER
金额:
$43.62万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2003
资助国家:
美国
项目状态:
已结题
起止时间:
2003-04-01 至 2007-03-31
关键词:
adult respiratory distress syndromebrain injurycellular immunityclinical researchclinical trialsdextranshelper T lymphocytehuman subjecthuman therapy evaluationhypovolemiainterleukin 10interleukin 2interleukin 4leukocyte activation /transformationmonocytemultiple organ failureneuroprotectantsneutrophiloutcomes researchpatient oriented researchresuscitationsalineshocktrauma
中文摘要
描述(由申请人提供):
英文摘要
DESCRIPTION (provided by applicant):
Conventional resuscitation of hypovolemic shock following traumatic injury involves the rapid administration of large volumes of lactated ringers (LR) solution. Previous research suggests that initial resuscitation with a hypertonic solution will result in more rapid restoration of blood pressure, improved cerebral perfusion, and modulation of the systemic inflammatory response to ischemia/reperfusion injury. This proposal seeks to evaluate the clinical outcome and inflammatory cell function of patients in shock following blunt traumatic injury who are randomized to receive 7.5% hypertonic saline/6% dextran (HSD) followed by LR versus LR alone. We hypothesize that HSD resuscitation will inhibit the initial excessive systemic activation of the inflammatory response, which will translate into a reduction in the incidence of organ dysfunction induced by this response. Furthermore, we seek to evaluate the impact of HSD resuscitation on recovery following traumatic brain injury, as previous studies suggest that this subgroup has the greatest survival advantage from this intervention. The specific aims for this proposal include: Aim 1: To determine the impact of pre-hospital administration of hypertonic saline/dextran on the development of organ failure following blunt traumatic injury with hypovolemic shock. Aim 2: To determine the impact of prehospital administration of hypertonic saline/dextran on the neurologic outcome following brain injury" for patients in hypovolemic shock. Aim 3a: To determine the effect of prehospital administration of hypertonic saline/dextran on the activation of circulating neutrophils and monocytes. Aim 3b: To determine the effect of prehospital administration of hypertonic saline/dextran on the activation of T lymphocytes. This proposal builds upon previous research which has demonstrated the safety and practicality of this resuscitation strategy in the prehospital environment. A more detailed understanding of the immuno-inflammatory effects of hypertonicity for all patients and the long-term neurologic outcome for patients with brain injury is critical to determining the role of this resuscitation approach in these critically injured patients.
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会议论文
A Deployment Focused Pragmatic Trial of Optimal Stepped Care Intervention Targeting PTSD and Comorbidity for Acutely Hospitalized Injury Survivors Treated in US Trauma Care Systems
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批准号:10506526
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项目类别:
-
资助金额:$79.02万
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财政年份:2022
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负责人:EILEEN M BULGER
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依托单位:
Pacific Northwest Clinical Center for the NHLBI PETAL Network
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批准号:8874280
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项目类别:
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资助金额:$38.34万
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财政年份:2014
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负责人:EILEEN M BULGER
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依托单位:
Pacific Northwest Clinical Center for the NHLBI PETAL Network
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批准号:9053366
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项目类别:
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资助金额:$34.98万
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财政年份:2014
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负责人:EILEEN M BULGER
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依托单位:
Pacific Northwest Clinical Center for the NHLBI PETAL Network
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批准号:8705819
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项目类别:
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资助金额:$14.5万
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财政年份:2014
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负责人:EILEEN M BULGER
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依托单位:
Hypertonic Modulation of Inflammation following Injury
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批准号:7442250
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项目类别:
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资助金额:$37.06万
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财政年份:2007
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负责人:EILEEN M BULGER
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依托单位:
Hypertonic Modulation of Inflammation following Injury
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批准号:7857900
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项目类别:
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资助金额:$30.18万
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财政年份:2007
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负责人:EILEEN M BULGER
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依托单位:
Hypertonic Modulation of Inflammation following Injury
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批准号:7625093
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项目类别:
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资助金额:$37.77万
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财政年份:2007
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负责人:EILEEN M BULGER
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依托单位:
Hypertonic Modulation of Inflammation following Injury
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批准号:7194735
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项目类别:
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资助金额:$39.59万
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财政年份:2007
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负责人:EILEEN M BULGER
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依托单位:
The Effect of Hypertonic Resuscitation for Blunt Trauma
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批准号:6595669
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项目类别:
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资助金额:$45.33万
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财政年份:2003
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负责人:EILEEN M BULGER
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依托单位:
The Effect of Hypertonic Resuscitation for Blunt Trauma
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批准号:6879925
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项目类别:
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资助金额:$37.26万
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财政年份:2003
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负责人:EILEEN M BULGER
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依托单位:
海外基金