Dental Composite with Reduced Polymerization Stress

聚合应力降低的牙科复合材料

• 批准号: 6765841
• 负责人: John R Condon
• 金额: $ 20.45万
• 依托单位: PROTO-TECH
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6765841
• 关键词: biomaterial development /preparation; biomaterial evaluation; composite resins; dental materials; infrared spectrometry; interferometry; oral facial restoration; oral facial restoration material; photoactivation; polymerization; polymers; propylene glycols

DESCRIPTION (provided by applicant): Dental composite restorative materials undergo shrinkage during their placement. When they are light-cured in a confined setting, the shrinkage they undergo generates stress at the bonded interface with the surrounding tooth structure. Often this stress is high enough to break the adhesive interface, causing a gap that leads to marginal staining, sensitivity and recurrent decay. This project will explore an alternative type of photo-initiator that can significantly reduce shrinkage stress. The new compound will be custom synthesized and its ability to initiate polymerization on a par with typical photo-initiator will be verified in a model composite using FTIR analysis. The polymerization stress of the model composite will be measured and compared with a composite containing typical photo-initiator. The in vitro wear resistance and fracture toughness of the composites containing novel initiator will be compared to composites containing typical initiator to ensure their clinical viability. Microleakage in class V restorations will be simulated in extracted human molars for the novel composites to demonstrate their superior marginal seal compared to a control composite. A composite that produces low polymerization stress would alleviate a long-standing problem in dentistry, with potential applications to other industries such as automobile and electronics manufacturing.

描述（由申请人提供）：牙科复合修复材料在放置过程中会发生收缩。当它们在有限的环境中进行光固化时，它们所经历的收缩会在与周围牙齿结构的粘合界面处产生应力。通常，这种应力足够高，足以破坏粘合界面，从而产生间隙，从而导致边缘染色、敏感性和反复衰减。该项目将探索一种可显着降低收缩应力的替代类型光引发剂。新化合物将进行定制合成，其引发聚合反应的能力与典型光引发剂相当，将在模型复合材料中使用 FTIR 分析进行验证。将测量模型复合材料的聚合应力，并将其与含有典型光引发剂的复合材料进行比较。含有新型引发剂的复合材料的体外耐磨性和断裂韧性将与含有典型引发剂的复合材料进行比较，以确保其临床可行性。新型复合材料将在人类拔出的磨牙中模拟 V 类修复体中的微渗漏，以证明其与对照复合材料相比具有优越的边缘密封效果。产生低聚合应力的复合材料将缓解牙科领域长期存在的问题，并有可能应用于汽车和电子制造等其他行业。