Real time detection and management antibiotic residues in milk

实时检测和管理牛奶中抗生素残留

• 批准号: 2440853
• 金额: --
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2440853
• 关键词: Real; time; detection; management; antibiotic

Antimicrobial drugs, such as antibiotics, are widely used in farming to treat a range of diseases caused by microorganisms. On dairy farms, there is a high risk that milk contaminated with antimicrobial residues contaminates the bulk storage tank and therefore milk destined for commercial use. Contaminated milk can no longer be sold resulting in large financial losses across the supply chain. Additionally, contaminated milk is disposed of in the environment, dispersing antimicrobials and potentially accelerating the emergence of antimicrobial resistance. The tests currently used to screen milk for antimicrobial residues are expensive or time consuming and only detect a limited range of residues. Furthermore, no technology currently exists that can monitor milking in real time and automatically preventing contamination of the bulk tank. The technology that will be developed through this PhD studentship will revolutionise real time monitoring of milk through the development of a smart inline sensor for the detection of antimicrobial residues (figure 1).This project results from a collaboration with the University of the West of Scotland in response to discussions with the Agricultural and Horticultural Development Board, National Farmers Union Scotland and the Scottish Dairy Hub. We also have the involvement of Graham's Family Dairy, as a key collaborator in the project, capable of providing essential in-kind support and industry insight. Together, this collaboration will deliver an industry focused technology with the capability to improve productivity, increase confidence of supply and reduce risk carried by farms and diaries.The studentship will focus upon the development of low cost printed sensors, combined with electrochemical techniques to create a fully integrated sensor and instrument, capable of identifying the presence of antimicrobial residues within milk. Molecularly Imprinted polymers (MIPs) will be developed and used as the basis to transduce the presence of antimicrobial residues into a measurable, monitored signal which can actuate a diversion valve to prevent bulk tank contamination. MIPs are attractive for this application because they can be produced at low cost, do not have cold chain storage requirements and are highly sensitive for the target analyte. The instrument used in conjunction with the sensor has already been prototyped and can be manufactured for under £5. We will combine this with a consumable sensor, produced for under £1. The project represents an excellent development opportunity for the PhD candidate, who will gain valuable experience at the interface between research and industry. The results and outcomes of the project will be used as a basis to apply for large commercialisation grants, such as innovateUK, ultimately to deliver commercial solutions. Our partnership includes the University of the West of Scotland, who are industry facing and have a strong network to deliver bench top and farm prototypes of the system.

抗菌药物，例如抗生素，广泛用于农业中以治疗一系列由微生物引起的疾病。在奶牛场，被抗菌剂残留物污染的牛奶很有可能污染散装储罐，从而污染用于商业用途的牛奶。受污染的牛奶无法再销售，导致整个供应链遭受巨大的财务损失。此外，受污染的牛奶被丢弃在环境中，导致抗菌剂扩散，并可能加速抗菌剂耐药性的出现。目前用于筛查牛奶中抗菌剂残留物的测试既昂贵又耗时，而且只能检测有限范围的残留物。此外，目前还没有能够实时监控挤奶并自动防止散装罐污染的技术。通过本博士生项目开发的技术将通过开发用于检测抗菌残留物的智能在线传感器来彻底改变牛奶的实时监控（图1）。该项目是与西苏格兰大学合作的结果，以回应与农业和园艺发展委员会、苏格兰国家农民联盟和苏格兰乳制品中心的讨论。我们还邀请 Graham's Family Dairy 作为该项目的主要合作者参与其中，能够提供必要的实物支持和行业洞察力。此次合作将共同提供一项以行业为中心的技术，能够提高生产力、增强供应信心并降低农场和奶牛场所承担的风险。该学生奖学金将重点开发低成本印刷传感器，并与电化学技术相结合，创建完全集成的传感器和仪器，能够识别牛奶中是否存在抗菌剂残留物。将开发分子印迹聚合物 (MIP) 并将其用作将抗菌残留物的存在转换为可测量的监测信号的基础，该信号可以驱动分流阀以防止散装储罐污染。 MIP 对于这种应用很有吸引力，因为它们可以低成本生产，没有冷链存储要求，并且对目标分析物高度敏感。与传感器结合使用的仪器已经完成原型设计，制造成本低于 5 英镑。我们将把它与消耗性传感器结合起来，生产成本不到 1 英镑。该项目为博士生提供了绝佳的发展机会，他们将在研究与工业界的交叉领域获得宝贵的经验。该项目的成果和成果将作为申请大型商业化资助（例如innovationUK）的基础，最终提供商业解决方案。我们的合作伙伴包括西苏格兰大学，他们面向行业并拥有强大的网络来提供系统的台式和农场原型。