Fiber Superluminescent Source for High Resolution OCT

用于高分辨率 OCT 的光纤超发光源

• 批准号: 6831811
• 负责人: Daniel Mahgerefteh
• 金额: $ 9.65万
• 依托单位: AZNA CORPORATION
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-02 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6831811
• 关键词: bioimaging /biomedical imaging; cost effectiveness; fiber optics; light emission; luminescence; optical tomography; technology /technique development

DESCRIPTION (provided by applicant): We propose to develop an entirely new broadband light source optimized for high-resolution optical coherence tomography (OCT). We propose to develop and refine techniques for manipulating the superluminescence properties of diode-pumped Ytterbuim-doped fiber in such a way as to decouple the output power and bandwidth. The goal is to develop a source offering >50mW of output with a bandwidth of at least 100nm and a nearly Gaussian spectral profile. The proposed technology development is intended to enable compact, efficient, cost effective sources appropriate for high-resolution clinical OCT. Clinical systems currently offered have imaging resolution of 10-20 mu/m, limited largely by the performance limitations of practical sources. This target specs proposed here will enable OCT resolution better than 5fm. This performance is particularly compelling for endoscopic minimally invasive biopsy where improved resolution can enhance the detection of cellular abnormalities. The technology may ultimately enable diagnostic quality, real-time optical biopsy.

描述（由申请人提供）： 我们建议开发一种全新的宽带光源，用于高分辨率光学相干断层扫描（OCT）。我们建议开发和完善的技术，用于操纵的超发光特性的二极管泵浦掺镱光纤的输出功率和带宽解耦的方式。我们的目标是开发一种输出功率大于50 mW、带宽至少为100 nm、光谱轮廓接近高斯分布的光源。 拟议的技术开发旨在使紧凑，高效，成本效益的来源，适用于高分辨率的临床OCT。临床系统目前提供的成像分辨率为10-20 μ/m，在很大程度上受到实际来源的性能限制。本文提出的目标规格将使OCT分辨率优于5 fm。这种性能对于内窥镜微创活检特别引人注目，其中提高的分辨率可以增强细胞异常的检测。该技术最终可能实现诊断质量，实时光学活检。