Technology To Assess the Risk of Cardiac Arrhythmias

评估心律失常风险的技术

• 批准号: 6790295
• 负责人: Joseph M Starobin
• 金额: $ 9.88万
• 依托单位: MEDIWAVE STAR TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6790295
• 关键词: arrhythmia; cardiovascular disorder diagnosis; cardiovascular disorder prevention; cardiovascular disorder risk; clinical research; computational biology; computer assisted diagnosis; computer data analysis; computer program /software; computer system design /evaluation; diagnosis design /evaluation; early diagnosis; heart function; human data; long QT syndrome; noninvasive diagnosis; patient oriented research; sudden cardiac death

DESCRIPTION (provided by applicant): Sudden cardiac death annually claims approximately 300,000 American lives. Its very name underscores the urgent need for an accurate methodology to assess an individual's risk of experiencing unstable cardiac propagation that may result in malignant arrhythmias. Our initial work has identified an inexpensive, sensitive diagnostic procedure to perform that assessment. Our proposed research will further explore the biophysical characteristics of unstable cardiac electrical propagation and suggest criteria useful for non-invasively assessing the risk of ventricular arrhythmias. QT and RR interval spatial and temporal variations are known to be intimately related to the stability of cardiac conduction. Our preliminary theoretical and experimental studies demonstrate that the stability can be assessed by measuring QT and RR intervals collected during an ECG stress test employing a proprietary quasi-stationary exercise protocol (i.e., with gradually changing exercise loads). This is a hypothesis that we propose to test by studying a mutual interdependence of the QT and RR interval fluctuations, which accompany the dynamics of the heart rate gradual trends during the quasi-stationary exercise. We will evaluate quantitative criteria for unstable cardiac conduction that are suggested by the physics and may serve as the basis for a new, non-invasive diagnostic tool for evaluating the risk of cardiac arrhythmias.

描述(由申请人提供)：心脏性猝死每年夺走大约30万美国人的生命。它的名字本身就强调了迫切需要一种准确的方法来评估个人经历可能导致恶性心律失常的不稳定心脏传播的风险。我们的初步工作已经确定了一种廉价、灵敏的诊断程序来进行这种评估。我们的研究将进一步探索心脏不稳定电传播的生物物理特征，并为无创评估室性心律失常的风险提出有用的标准。QT间期和RR间期的空间和时间变化与心脏传导的稳定性密切相关。我们的初步理论和实验研究表明，可以通过测量在采用专有的准静态运动方案(即，在逐渐变化的运动负荷下)进行心电负荷测试期间收集的QT和RR间期来评估稳定性。这是一个假设，我们建议通过研究QT和RR间期波动之间的相互依赖来检验这一假设，QT和RR间期波动伴随着准静态运动期间心率渐进趋势的动态变化。我们将评估物理学提出的心脏传导不稳定的定量标准，并可能作为评估心律失常风险的新的非侵入性诊断工具的基础。