A clinically Practical 6.45 mum Pulsed Surgical Laser

描述（由申请人提供）： 一项广泛的研究表明，在临床上有意义的背景下，已经努力在各种波长和波长范围内优化激光辐射和人体组织的相互作用。在这方面，自由电子激光器（FEL）已经并将继续发挥重要作用。最近几项自由电子激光研究的结果表明，在一定的脉冲条件下，6.45 μ m的辐射是理想的，几乎所有的软组织的消融和精确切除。到目前为止，唯一有用的高能6.45 μ m辐射源仍然是一个设施大小的自由电子激光。 在这里，Light Age提出开发一种更简单的固态激光源，能够提供与6.45 μ m FEL相同的理想组织消融特性，但其形式更加“临床友好”和负担得起。在这方面，我们计划利用我们开创的某些光学技术的融合：广泛可调谐，固态，临床证明的紫翠宝石激光器;强大的，商业和临床实用的再循环拉曼转换器;以及在很大程度上认识不足，目前尚未商业化的腔内拉曼转换（ICR）技术。我们讨论了所提出的方法如何克服某些经典的问题，在产生6.45 μ m的光功率水平被认为是必要的最佳临床疗效。这项工作的结果将是一个新的医学研究工具，允许进行更广泛的临床研究，并在结论性评估后，可以优雅地进入和适应一般的临床环境。

DESCRIPTION (provided by applicant): An extensive research spent identifies, clinically significant contexts, effort have been to within various the wavelengths and wavelength ranges that optimize the interaction of laser radiation and human tissues. In this, Free Electron Lasers (FELs) have played and continue to play a major role. The results of several recent FEL studies have indicated that under certain pulsed conditions 6.45mu m radiation is ideal for the iablation and precise excision of nearly all soft tissue. To date the only useful source of high energy 6.45mu m radiation remains a facility-sized FEL. Here Light Age proposes to develop a simpler, solid-state laser source able to provide the same desirable tissue ablation characteristics of the FEL's at 6.45mu m but in vastly more "clinically friendly" and affordable format. In this, we plan to exploit a convergence of certain optical technologies we have pioneered: the broadly tunable, solid-state, clinically proven alexandrite laser; robust, commercially and clinically practical recirculating Raman converters; and the largely under-recognized and presently uncommercialized technique of intra-cavity Raman conversion (ICR). We discuss how the proposed approach surmounts certain classic problems in generating 6.45mu m light at power levels deemed requisite for optimal clinical efficacy. The result of this work will be a new tool for medical research that permits more widespread clinical studies to be conducted and, upon conclusive evaluation, can gracefully enter and adapt to the general clinical environment.